Description

6-Deamino-2-[(Trimethylsilyl)Amino]-6-[(Trimethylsilyl)Oxy]-2'-O,3'-o-Bis(Trimethylsilyl)Adenosine 5'-[Phosphoric Acid Bis(Trimethylsilyl)] Ester is a highly specialized, fully silylated adenosine derivative designed for advanced synthetic chemistry applications. This compound is critical for researchers and manufacturers requiring precise protection of reactive functional groups, particularly in nucleoside and nucleotide chemistry. It serves as a key protected intermediate for the synthesis of modified oligonucleotides, prodrugs, and other bioactive molecules in pharmaceutical and biotechnology R&D.

Application

• Intermediate for Oligonucleotide Synthesis: Used as a protected phosphoramidite precursor in the solid-phase synthesis of antisense oligonucleotides, siRNA, and aptamers.
• Prodrug Development: Acts as a key building block for creating nucleoside prodrugs with enhanced membrane permeability and metabolic stability.
• Medicinal Chemistry Research: Employed in the synthesis of novel adenosine receptor ligands and other nucleoside-based therapeutic candidates.
• Bioconjugation and Labeling: Serves as a starting material for introducing modified nucleosides into biomolecules for diagnostic or tracking purposes.
• Process Chemistry: Utilized in the scalable production of high-value nucleoside analogs under controlled, anhydrous conditions.
• Academic & Institutional Research: A valuable reagent for studying nucleoside chemistry, reaction mechanisms, and developing new synthetic methodologies.

Basic Information

Product Name	6-Deamino-2-[(Trimethylsilyl)Amino]-6-[(Trimethylsilyl)Oxy]-2'-O,3'-o-Bis(Trimethylsilyl)Adenosine 5'-[Phosphoric Acid Bis(Trimethylsilyl)] Ester
CAS No.	32653-15-9
Molecular Formula	C29H63N5O7P Si5
Molecular Weight	770.31 g/mol
Synonyms	2',3'-O-Bis(trimethylsilyl)-N6,O6-bis(trimethylsilyl)-2,6-diaminopurine riboside 5'-(bis(trimethylsilyl) phosphate); 2,6-Bis(trimethylsilylamino)-9-[2,3-bis-O-(trimethylsilyl)-β-D-ribofuranosyl]purine 5'-(bis(trimethylsilyl) phosphate); Fully Silylated Adenosine Phosphate Ester; N2,N6,O2',O3',O5'-Pentakis(trimethylsilyl)adenosine; Per-TMS Adenosine Phosphate Derivative; 32653-15-9; Protected Adenosine Intermediate
EINECS	Contact for details

Quality Control

Every batch of this high-purity synthetic intermediate is produced and analyzed under strict quality management systems. We provide comprehensive Certificates of Analysis (COA) detailing identity, purity, and impurity profiles to ensure consistency and reliability for your critical research and development processes. Our quality protocols are designed to meet the stringent requirements of pharmaceutical R&D and cGMP environments where applicable.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C in a dry, inert atmosphere (e.g., under argon or nitrogen) due to its hygroscopic and moisture-sensitive nature. Allow the sealed container to reach room temperature before opening to prevent condensation and hydrolysis.

Specification

Item	Specification
Appearance	White to off-white solid or viscous oil
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 95.0%
Purity (HPLC, Area%)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.