Description

2'-Deoxy-n-(Trimethylsilyl)-3'-o-(Trimethylsilyl)Adenosine 5'-[Phosphoric Acid Bis(Trimethylsilyl)] Ester is a key protected nucleoside derivative, specifically designed for advanced oligonucleotide synthesis. This compound is critical for researchers and manufacturers requiring high-purity, reactive intermediates for the controlled assembly of DNA and RNA analogs. It is primarily utilized in pharmaceutical R&D, biotechnology, and academic laboratories focused on developing novel therapeutics, diagnostic probes, and molecular biology tools.

Application

• Solid-Phase Oligonucleotide Synthesis (SPOS): Acts as a crucial, protected phosphoramidite precursor for automated DNA/RNA synthesizers.
• Antisense & siRNA Therapeutic Development: Serves as a building block for creating modified oligonucleotides with enhanced stability and target affinity.
• Diagnostic Probe Manufacture: Used in the production of labeled probes for PCR, sequencing, and microarray applications.
• Academic & Industrial Research: Enables the study of nucleic acid chemistry, enzyme mechanisms, and the synthesis of novel nucleoside analogs.
• Process Development & Scale-Up: Supports the transition from milligram-scale discovery to gram/kilogram-scale production for clinical trial materials.

Basic Information

Product Name	2'-Deoxy-n-(Trimethylsilyl)-3'-o-(Trimethylsilyl)Adenosine 5'-[Phosphoric Acid Bis(Trimethylsilyl)] Ester
CAS No.	32645-70-8
Molecular Formula	C24H50N5O6PSi4
Molecular Weight	656.02 g/mol
Synonyms	5'-O-[Bis(trimethylsilyl)phosphoryl]-2'-deoxy-N,3'-O-bis(trimethylsilyl)adenosine; 2'-Deoxyadenosine, 5'-[bis(trimethylsilyl) phosphate], N,3'-bis(trimethylsilyl)-; Protected 2'-Deoxyadenosine Phosphotriester; TMS-Protected dA Intermediate; N,3',5'-Tris-O-trimethylsilyl-2'-deoxyadenosine Phosphotriester; dA(TMS)3 Phosphotriester; Adenosine, 2'-deoxy-N-(trimethylsilyl)-3'-O-(trimethylsilyl)-, 5'-[phosphoric acid bis(trimethylsilyl) ester]
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Every batch is characterized using advanced analytical techniques including HPLC, NMR, and mass spectrometry to confirm identity, purity, and stability. Certificates of Analysis (COA) detailing batch-specific results are available upon request. We adhere to GMP-grade handling procedures for high-value synthetic intermediates to guarantee consistency and reliability for your critical research and production needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label or COA. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions, such as in a glove box or under a dry inert atmosphere (argon/nitrogen), to maintain stability and reactivity. Allow the sealed container to reach room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white powder or solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.