Description

Thymidine Glycol CAS NO 32645-65-1 is a modified nucleoside derivative, specifically a glycolated form of thymidine. This compound is of significant interest in biochemical and pharmaceutical research due to its role as a biomarker for oxidative DNA damage. It is primarily utilized by research institutions, diagnostic developers, and pharmaceutical companies engaged in studies related to oxidative stress, mutagenesis, and the development of analytical standards for DNA lesion detection.

Application

• Biomarker Research: Used as a standard reference material for the quantification of oxidative DNA lesions, such as 5,6-dihydroxy-5,6-dihydrothymidine, in cellular and tissue samples.
• Analytical Chemistry: Serves as a critical calibration standard in advanced analytical techniques including Liquid Chromatography-Mass Spectrometry (LC-MS/MS) and Gas Chromatography-Mass Spectrometry (GC-MS).
• Pharmaceutical Development: Employed in studies investigating the efficacy of antioxidants and chemoprotective agents against oxidative DNA damage.
• Diagnostic Assay Development: Integral to the development and validation of diagnostic kits and assays designed to measure oxidative stress levels in clinical and research settings.
• Toxicology Studies: Used to assess the genotoxic impact of environmental toxins, radiation, and pharmaceutical compounds.
• Academic Research: A key reagent in molecular biology and biochemistry laboratories for fundamental research on DNA repair mechanisms and genome stability.

Basic Information

Product Name	Thymidine Glycol
CAS No.	32645-65-1
Molecular Formula	C10H14N2O6
Molecular Weight	258.23 g/mol
Synonyms	5,6-Dihydroxy-5,6-dihydrothymidine; 5,6-Dihydroxydihydrothymidine; Thymine glycol; 1-(2-Deoxy-β-D-erythro-pentofuranosyl)-5,6-dihydroxy-5,6-dihydrothymine; 5,6-Dihydroxy-5,6-dihydro-2'-deoxythymidine; dThg; Oxidized Thymidine
EINECS	Contact for details

Quality Control

Our Thymidine Glycol is produced under stringent quality management protocols. Each batch undergoes comprehensive analytical testing to ensure high purity and consistency, meeting the exacting standards required for research and diagnostic applications. A detailed Certificate of Analysis (COA) providing purity, identity, and impurity profile data is supplied with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Related Substances (HPLC)	Total impurities ≤ 5.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.