Description

2-O,3-O,5-o-Tris(Trimethylsilyl)-D-Arabinoic Acid γ-Lactone is a key protected sugar derivative, specifically a silylated lactone, used as a versatile chiral building block in advanced organic synthesis. Its primary value lies in providing a stable, reactive intermediate for the stereoselective construction of complex molecules, particularly nucleosides and carbohydrates. This high-purity compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and fine chemical industries who require reliable, high-quality intermediates for process development and API synthesis.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of novel nucleoside analogs and antiviral/anticancer drug candidates.
• Carbohydrate Chemistry: Serves as a protected starting material for the preparation of complex oligosaccharides, glycoconjugates, and glycomimetics.
• Chiral Pool Synthesis: Utilized as a chiral template for the asymmetric synthesis of natural products and bioactive molecules.
• Agrochemical Research: Employed in developing new active ingredients with specific stereochemical configurations.
• Process Chemistry: Used in route scouting and scale-up for the production of fine chemicals and advanced intermediates.
• Academic & R&D: A valuable reagent for methodological studies in synthetic organic chemistry and medicinal chemistry programs.

Basic Information

Product Name	2-O,3-O,5-o-Tris(Trimethylsilyl)-D-Arabinoic Acid γ-Lactone
CAS No.	32384-55-7
Molecular Formula	C15H34O5Si3
Molecular Weight	390.68 g/mol
Synonyms	2,3,5-Tri-O-(trimethylsilyl)-D-arabinono-1,4-lactone; D-Arabinono-1,4-lactone, 2,3,5-tris-O-(trimethylsilyl)-; Tris(trimethylsilyl) D-arabinonolactone; 2,3,5-Tris-O-trimethylsilyl-D-arabinono-γ-lactone; Protected D-Arabinono-1,4-lactone; TMS-protected Arabinonolactone; Silylated Arabinonic Acid Lactone
EINECS	Contact for details

Quality Control

Every batch of 2-O,3-O,5-o-Tris(Trimethylsilyl)-D-Arabinoic Acid γ-Lactone is produced and tested under a strict quality management system. We ensure compliance with high-purity standards suitable for research and commercial synthesis. Comprehensive analytical testing, including HPLC, GC, NMR, and chiral purity analysis, is performed to guarantee identity, potency, and consistency. A detailed Certificate of Analysis (COA) documenting all specifications is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be handled under anhydrous conditions to maintain stability and purity. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline solid or powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Chiral Purity	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.