Description

(S)-Phenoxybenzamine Hydrochloride is a high-purity, enantiomerically pure pharmaceutical intermediate and research chemical. This compound is critical for the development and production of selective α-adrenergic receptor antagonists. It is primarily utilized by pharmaceutical R&D laboratories, academic research institutions, and manufacturers of active pharmaceutical ingredients (APIs) for pharmacological studies and process development.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of enantiomerically pure α-blocker APIs.
• Biochemical Research: Selective antagonist for α-1 and α-2 adrenergic receptors in pharmacological and signal transduction studies.
• Reference Standard: Used as a certified reference material (CRM) in analytical method development and quality control laboratories.
• Preclinical Development: Employed in animal model studies to investigate cardiovascular effects and autonomic nervous system modulation.
• Process Chemistry: Serves as a chiral template or starting material for the development of stereoselective synthetic routes.

Basic Information

Item	Details
Product Name	(S)-Phenoxybenzamine Hydrochloride
CAS No.	32378-29-3
Molecular Formula	C18H22ClNO2 • HCl
Molecular Weight	340.29 g/mol
Synonyms	(S)-N-(2-Chloroethyl)-N-(1-methyl-2-phenoxyethyl)benzylamine Hydrochloride; (S)-Phenoxybenzamine HCl; (S)-POB HCl; (S)-Dibenzyline Hydrochloride; (S)-N-Phenoxyisopropyl-N-benzyl-β-chloroethylamine Hydrochloride; (S)-Benzyl(2-chloroethyl)(1-methyl-2-phenoxyethyl)amine Hydrochloride; (S)-Enantiomer of Phenoxybenzamine Hydrochloride
EINECS	Contact for details

Quality Control

Our (S)-Phenoxybenzamine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets stringent specifications for pharmaceutical research. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee identity, purity, and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Loss on Drying	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.