Description

n-(3-Methyl-3-Butenyl)-2'-O,3'-O,5'-o-Tris(Trimethylsilyl)Adenosine is a chemically modified nucleoside derivative, specifically a silyl-protected adenosine analog. This compound is of significant value in organic synthesis and pharmaceutical research, where it serves as a crucial protected intermediate for the controlled construction of complex nucleotide-based molecules. It is primarily needed by research institutions and manufacturers in the pharmaceutical, agrochemical, and fine chemical industries for developing novel therapeutics, diagnostic probes, and advanced materials.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel adenosine receptor agonists/antagonists and other nucleoside-based drug candidates.
• Oligonucleotide Synthesis: Used as a protected monomer in solid-phase or solution-phase synthesis of modified DNA/RNA strands for research and therapeutic applications.
• Prodrug Development: Serves as a precursor for creating prodrug forms of antiviral or anticancer nucleoside analogs to improve bioavailability and targeting.
• Bioconjugation & Labeling: The reactive isopentenyl and silyl-protected hydroxyl groups provide handles for site-specific conjugation with fluorophores, lipids, or other functional moieties.
• Chemical Biology Research: Employed in studying enzyme mechanisms (e.g., tRNA isopentenyltransferases) and metabolic pathways involving prenylated nucleosides.
• Fine Chemical Synthesis: Valuable intermediate for synthesizing complex natural products and specialty chemicals that incorporate modified nucleoside structures.

Basic Information

Item	Detail
Product Name	n-(3-Methyl-3-Butenyl)-2'-O,3'-O,5'-o-Tris(Trimethylsilyl)Adenosine
CAS No.	32352-58-2
Molecular Formula	C27H51N5O4Si3
Molecular Weight	606.0 g/mol (approx.)
Synonyms	N6-(3-Methyl-2-buten-1-yl)-2',3',5'-O-tris(trimethylsilyl)adenosine; 2',3',5'-Tri-O-trimethylsilyl-N6-(3-methyl-2-butenyl)adenosine; N6-(δ2-Isopentenyl)-2',3',5'-tri-O-TMS-adenosine; N6-(γ,γ-Dimethylallyl)-2',3',5'-tri-O-(trimethylsilyl)adenosine; Protected i6A; TMS-protected iPA; Silylated N6-isopentenyladenosine
EINECS	Contact for details

Quality Control

Our n-(3-Methyl-3-Butenyl)-2'-O,3'-O,5'-o-Tris(Trimethylsilyl)Adenosine is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and KF titration for moisture content, to ensure it meets the stringent requirements for research and synthesis. Certificates of Analysis (COA) with detailed chromatograms and spectral data are provided to guarantee traceability and consistency for your critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This material is hygroscopic (moisture-sensitive); containers must be kept tightly sealed in a desiccated environment to prevent degradation. For long-term storage, consider storing under an inert atmosphere such as argon or nitrogen.

Specification

Item	Specification
Appearance	White to off-white powder or solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (NMR)	Spectrum consistent with structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.