Description

2'-Deoxy-Tetrahydro-5'-Uridylic Acid is a modified nucleoside monophosphate derivative of uridine, where the ribose sugar is deoxygenated at the 2' position and the uracil base is in a tetrahydro (fully saturated) state. This unique structure makes it a valuable intermediate and building block in advanced pharmaceutical research and development. It is primarily utilized by research institutions and pharmaceutical companies engaged in the synthesis of novel nucleoside analogs, prodrug development, and biochemical studies targeting enzyme mechanisms and metabolic pathways.

Application

• Pharmaceutical Intermediate: A key synthetic precursor for the development of novel antiviral and anticancer nucleoside analogs.
• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies, particularly those involving thymidylate synthase and other nucleotide-metabolizing enzymes.
• Prodrug Synthesis: Serves as a core structure for designing prodrugs aimed at improving bioavailability and targeted delivery of therapeutic agents.
• Reference Standard: Employed as a high-purity analytical standard in quality control and method development for pharmaceutical manufacturing.
• Metabolic Pathway Studies: Utilized in research to investigate nucleotide salvage pathways and DNA repair mechanisms.
• Antisense Oligonucleotide Research: Can be incorporated into modified oligonucleotides for studying gene expression and silencing.

Basic Information

Product Name	2'-Deoxy-Tetrahydro-5'-Uridylic Acid
CAS No.	32017-56-4
Molecular Formula	C9H14N2O8P
Molecular Weight	294.19 g/mol
Synonyms	2'-Deoxy-5,6-dihydro-5'-uridylic acid; 2'-Deoxy-5,6-dihydrouridine 5'-monophosphate; 5,6-Dihydro-2'-deoxyuridine 5'-monophosphate; THdUMP; Tetrahydro-2'-deoxyuridine 5'-monophosphate; 2'-Deoxy-5,6-dihydro-UMP; Dihydro-2'-deoxyuridine monophosphate
EINECS	Contact for details

Quality Control

Our 2'-Deoxy-Tetrahydro-5'-Uridylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods (NMR, IR, MS). We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters to ensure compliance with your research or development requirements. Specifications can be aligned with cGMP standards for advanced pharmaceutical applications upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.