Description

8-Thioethyladenosine 3':5'-Cyclic Monophosphate is a chemically modified derivative of cyclic adenosine monophosphate (cAMP), a fundamental secondary messenger in cellular signaling pathways. This thioether-modified analog is valued for its enhanced stability and unique biological activity, making it a critical tool for probing and modulating cAMP-dependent processes. It is primarily utilized by researchers and developers in pharmaceutical R&D, biochemical research, and diagnostic assay development to study signal transduction, enzyme regulation, and receptor-ligand interactions.

Application

• Biochemical Research: As a stable analog of cAMP for studying protein kinase A (PKA) activation and other cAMP-mediated signaling cascades.
• Pharmaceutical Development: Serves as a key reference standard or intermediate in the discovery of drugs targeting cardiovascular, metabolic, and neurological disorders.
• Enzyme Studies: Used as a substrate or inhibitor in assays for phosphodiesterases (PDEs) and adenylate cyclases to evaluate enzyme kinetics and inhibition.
• Cell Biology: Investigation of intracellular calcium mobilization, ion channel regulation, and gene expression controlled by cAMP pathways.
• Diagnostic Reagents: Potential component in the development of high-sensitivity immunoassays or biosensors for clinical diagnostics.

Basic Information

Product Name	8-Thioethyladenosine 3':5'-Cyclic Monophosphate
CAS No.	31966-51-5
Molecular Formula	C12H16N5O6PS
Molecular Weight	389.33 g/mol
Synonyms	8-(2-Thioethyl)adenosine 3',5'-cyclic monophosphate; 8-Thioethyl-cAMP; 8-SEA-cAMP; 8-(2-Thioethyl)adenosine cyclic 3',5'-(hydrogen phosphate); cAMP, 8-(2-thioethyl)-; 8-(2-Mercaptoethyl)adenosine 3',5'-cyclic monophosphate; 8-(2-Thioethyl)-cAMP; 8-Thioethyladenosine cyclic phosphate
EINECS	Contact for details

Quality Control

Our 8-Thioethyladenosine 3':5'-Cyclic Monophosphate is manufactured under controlled conditions to ensure high purity and batch-to-batch consistency. Quality is verified through a comprehensive suite of analytical techniques including HPLC, NMR, and mass spectrometry. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each batch to support your research and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 3.0%
Solubility	Soluble in water, DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.