Description

2'-Deoxy-3,4,5,6-Tetrahydrouridine is a modified nucleoside analog that functions as a potent inhibitor of cytidine deaminase. This compound is critical for research and development in the life sciences, where it is used to stabilize cytidine analogs and modulate nucleotide metabolism. It is primarily utilized by pharmaceutical researchers, biotechnology companies, and academic institutions engaged in oncology, antiviral, and metabolic disorder studies.

Application

• Pharmaceutical Research & Development: As a key biochemical tool for studying cytidine deaminase activity and for the development of nucleoside-based therapeutics.
• Oncology Research: Used to enhance the efficacy and stability of cytarabine and other deoxycytidine analogs in cancer cell studies and preclinical models.
• Antiviral Drug Development: Employed in research focused on nucleoside reverse transcriptase inhibitors to improve metabolic stability.
• Biochemical Assays: Serves as a standard or reference compound in enzymatic assays targeting pyrimidine metabolism pathways.
• Academic & Contract Research: Utilized in universities and CROs for fundamental research into nucleotide salvage pathways and enzyme kinetics.

Basic Information

Product Name	2'-Deoxy-3,4,5,6-Tetrahydrouridine
CAS No.	31962-88-6
Molecular Formula	C9H14N2O5
Molecular Weight	230.22 g/mol
Synonyms	2'-Deoxy-3,4,5,6-tetrahydro-uridine; 2'-Deoxy-tetrahydrouridine; dTHU; NSC 112907; 1-(2-Deoxy-β-D-erythro-pentofuranosyl)-1,2,3,4-tetrahydro-2,4-dioxopyrimidine; Tetrahydrouridine, 2'-deoxy-; 2'-Deoxy-THU; 2'-Deoxy-3,4,5,6-tetrahydro-2,4-dioxo-1(2H)-pyrimidinepentofuranoside
EINECS	Contact for details

Quality Control

Our 2'-Deoxy-3,4,5,6-Tetrahydrouridine is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and tests for residual solvents and moisture. Certificates of Analysis (COA) detailing all specifications are provided to ensure compliance with your research and development requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.