Description

2-Nitrophenyl Chlorothioformate is a specialized organosulfur reagent used as a key building block in advanced organic synthesis. Its primary value lies in its role as a versatile intermediate for introducing protected thiol functionalities and constructing heterocyclic scaffolds. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, particularly for the synthesis of active pharmaceutical ingredients (APIs) and novel crop protection agents.

Application

• Pharmaceutical Intermediate: A critical reagent for the synthesis of complex molecules, including potential drug candidates and active pharmaceutical ingredients (APIs).
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides requiring specific sulfur-containing motifs.
• Peptide Chemistry: Serves as a coupling agent or protecting group precursor in the synthesis of modified peptides and peptidomimetics.
• Material Science Research: Employed in the creation of functionalized polymers and advanced materials with tailored properties.
• Chemical Biology Probes: Utilized for labeling and modifying biomolecules to study biological processes and interactions.
• Cross-coupling Reactions: Acts as an electrophile in palladium-catalyzed and other transition metal-mediated coupling reactions.

Basic Information

Product Name	2-Nitrophenyl Chlorothioformate
CAS No.	31836-20-1
Molecular Formula	C7H4ClNO3S
Molecular Weight	217.63 g/mol
Synonyms	2-Nitrophenyl Chlorothioformate; o-Nitrophenyl Chlorothioformate; Chlorothioformic Acid O-(2-Nitrophenyl) Ester; Phenyl Chlorothioformate, 2-nitro-; 2-Nitrobenzenyl Chlorothioformate; NSC 163081; 2-Nitrophenyl Chlorothionoformate; (2-Nitrophenoxy)carbonothioic Chloride
EINECS	Contact for details

Quality Control

Our 2-Nitrophenyl Chlorothioformate is manufactured under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent degradation. Keep away from heat, sparks, open flames, and incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	Yellow to light brown crystalline solid or powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.