Description

5'-Chloro-5'-Deoxycytidine is a modified nucleoside analog, a key synthetic intermediate in the development of antiviral and anticancer pharmaceuticals. Its primary value lies in its role as a versatile building block for the synthesis of more complex nucleotide derivatives and prodrugs, enabling targeted therapeutic action. This high-purity intermediate is essential for research institutions and pharmaceutical manufacturers focused on nucleoside-based drug discovery, particularly in antiviral therapies.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of novel antiviral and anticancer nucleoside analogs.
• Antiviral Drug Research: Used in the development of prodrugs targeting viral polymerases for diseases such as hepatitis and herpes.
• Oncology Research: Serves as a building block for creating cytostatic agents that interfere with DNA synthesis in cancer cells.
• Biochemical Tool: Employed in enzymatic studies and as a substrate analog to investigate nucleoside metabolism pathways.
• Labeled Compound Synthesis: A starting material for producing isotopically labeled (e.g., 13C, 15N) compounds for metabolic tracing and pharmacokinetic studies.
• Oligonucleotide Modification: Used to introduce specific modifications into oligonucleotides for therapeutic or diagnostic applications.

Basic Information

Product Name	5'-Chloro-5'-Deoxycytidine
CAS No.	31652-78-5
Molecular Formula	C9H12ClN3O4
Molecular Weight	261.66 g/mol
Synonyms	5'-Chloro-5'-deoxycytidine; 5'-Chloro-2'-deoxycytidine; 1-(5-Chloro-5-deoxy-β-D-ribofuranosyl)cytosine; 5-Chloro-5-deoxycytidine; Cytidine, 5'-chloro-5'-deoxy-; 5'-Chloro-2'-deoxy-cytidine; 5'-Cl-5'-dCyd
EINECS	Contact for details

Quality Control

Our 5'-Chloro-5'-Deoxycytidine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, identity confirmation by IR and NMR spectroscopy, and residual solvent analysis, to ensure it meets the high standards required for pharmaceutical research and development. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept in a desiccated environment to prevent moisture absorption, which may affect stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH guidelines
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.