Description

Diethyl (Tosyloxy)Methylphosphonate is a specialized organophosphorus compound that serves as a versatile reagent in synthetic organic chemistry. Its primary value lies in its role as a key intermediate for the Horner-Wadsworth-Emmons (HWE) olefination reaction, enabling the efficient synthesis of alkenes and complex molecular frameworks. This high-purity building block is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors who require reliable and consistent synthetic pathways.

Application

• Pharmaceutical Intermediate: Critical building block for synthesizing active pharmaceutical ingredients (APIs), particularly those containing alkene functionalities.
• Agrochemical Synthesis: Used in the production of advanced pesticides, herbicides, and plant growth regulators.
• Material Science Research: Employed in the development of novel polymers, liquid crystals, and organic electronic materials.
• Academic & R&D Laboratories: A fundamental reagent for method development and exploring new Horner-Wadsworth-Emmons reaction methodologies.
• Fine Chemical Production: Facilitates the synthesis of complex fragrance and flavor compounds.
• Cross-Coupling Reactions: Acts as a precursor for generating phosphonate-stabilized carbanions used in C-C bond formation.

Basic Information

Product Name	Diethyl (Tosyloxy)Methylphosphonate
CAS No.	31618-90-3
Molecular Formula	C12H19O6PS
Molecular Weight	322.31 g/mol
Synonyms	Diethyl (p-Toluenesulfonyloxy)methylphosphonate; Diethyl (4-Methylbenzenesulfonyloxy)methylphosphonate; (Tosyloxymethyl)phosphonic Acid Diethyl Ester; Phosphonic Acid, P-[(4-Methylphenyl)sulfonyl]oxymethyl]-, Diethyl Ester; Diethyl (Tosyloxy)Methylphosphonate; HWE Reagent; Horner-Wadsworth-Emmons Reagent; DTMP
EINECS	Contact for details

Quality Control

Our Diethyl (Tosyloxy)Methylphosphonate is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity for demanding synthetic applications. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as assay, identity, and impurity profiles. Our quality management system is designed to meet the stringent requirements of GMP and ISO standards for chemical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed and under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent decomposition. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.