Description

2'-C-Methyluridine is a modified nucleoside analog of significant interest in advanced pharmaceutical research and development. Its unique structure, featuring a methyl group at the 2'-carbon position of the ribose sugar, makes it a valuable building block for the synthesis of novel therapeutic agents. This compound is primarily utilized by research institutions and pharmaceutical companies engaged in the development of antiviral drugs, anticancer therapies, and other nucleotide-based medicines.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of nucleoside analog prodrugs for antiviral applications, particularly against hepatitis C virus (HCV).
• Antiviral Drug Research: Serves as a core scaffold for developing polymerase inhibitors that target viral replication mechanisms.
• Oncology Research: Used in the development of chemotherapeutic agents designed to interfere with cancer cell DNA/RNA synthesis.
• Biochemical Research: Employed as a substrate or inhibitor in enzymatic studies to understand nucleic acid metabolism and related pathways.
• Proteomics & Genomics: Acts as a modified base in oligonucleotide synthesis for research tools, diagnostic probes, and antisense technologies.
• Medicinal Chemistry: A key starting material for structure-activity relationship (SAR) studies to optimize drug potency and selectivity.

Basic Information

Product Name	2'-C-Methyluridine
CAS No.	31448-54-1
Molecular Formula	C10H14N2O6
Molecular Weight	258.23 g/mol
Synonyms	2'-C-Methyluridine; 1-((2R,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)-3-methyltetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione; 2'-Methyluridine; 2'-C-Me-U; 2'-C-Methyl Uridine; β-D-2'-C-Methyluridine; Uridine, 2'-C-methyl-
EINECS	Contact for details

Quality Control

Our 2'-C-Methyluridine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and pharmaceutical applications. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing purity, identity, and impurity profiles as determined by advanced analytical techniques including HPLC, NMR, and mass spectrometry. Our quality commitment aligns with cGMP principles for active pharmaceutical ingredients (APIs).

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms to reference spectrum
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.