Description

3β-(Acetyloxy)-14-Hydroxy-15-Oxo-5β-Bufa-20,22-Dienolide CAS NO 31444-12-9 is a high-purity bufadienolide derivative, a specialized class of steroid-like compounds with significant biological activity. This compound is valued for its role as a critical pharmaceutical intermediate and reference standard in advanced research and development. It is primarily sought by pharmaceutical manufacturers and biochemical research institutions for the synthesis and study of novel therapeutic agents.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel cardioactive and anticancer drug candidates.
• Biochemical Research: Used as a reference standard and probe in pharmacological studies to investigate cellular signaling pathways and ion channel modulation.
• Analytical Standard: Serves as a high-purity certified reference material (CRM) for quality control and method validation in analytical laboratories.
• Natural Product Chemistry: Employed in the study and semi-synthesis of complex natural products derived from toad venom and related sources.
• Preclinical Development: Utilized in the early-stage development and screening of new molecular entities targeting specific biological receptors.

Basic Information

Product Name	3β-(Acetyloxy)-14-Hydroxy-15-Oxo-5β-Bufa-20,22-Dienolide
CAS No.	31444-12-9
Molecular Formula	C₂₆H₃₄O₆
Molecular Weight	442.55 g/mol
Synonyms	14-Hydroxy-3β-acetoxy-15-oxo-5β-bufa-20,22-dienolide; 3β-Acetoxy-14-hydroxy-15-oxo-5β-bufa-20,22-dienolide; Bufadienolide derivative; 3β-Acetoxy-14,15-dihydroxybufa-20,22-dienolide (related); Marinobufagenin 3-acetate (related); Toad venom steroid analog; 5β-Bufa-20,22-dienolide-3β,14-diol-15-one 3-acetate
EINECS	Contact for details

Quality Control

Our 3β-(Acetyloxy)-14-Hydroxy-15-Oxo-5β-Bufa-20,22-Dienolide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and spectroscopic identification (NMR, MS), to ensure it meets exacting standards for research and pharmaceutical use. Certificates of Analysis (COA) with detailed specifications are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a desiccated environment to prevent degradation. For long-term storage, consider inert atmosphere conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.