Description

3β,14,15α-Trihydroxy-5β,14β-Bufa-20,22-Dienolide is a specialized bufadienolide compound, a class of cardioactive steroids. This high-purity intermediate is critical for pharmaceutical research and development, particularly in the study of cardiac glycosides and their therapeutic mechanisms. It serves as a key building block for researchers and manufacturers in the pharmaceutical and biotechnology sectors requiring precise, well-characterized chemical entities for drug discovery and synthesis.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel cardioactive steroid derivatives and potential therapeutic agents.
• Biochemical Research: Used as a reference standard and active compound in studies investigating Na+/K+-ATPase inhibition and cardiac cell signaling pathways.
• Drug Discovery: Serves as a core scaffold for medicinal chemistry programs aimed at developing new treatments for heart failure and related conditions.
• Analytical Standard: Employed in HPLC, LC-MS, and other analytical methods for the identification and quantification of bufadienolides in complex matrices.
• Natural Product Chemistry: Used in the study and semi-synthesis of compounds derived from traditional medicinal sources like toad venom.

Basic Information

Product Name	3β,14,15α-Trihydroxy-5β,14β-Bufa-20,22-Dienolide
CAS No.	31444-11-8
Molecular Formula	C₂₄H₃₄O₅
Molecular Weight	402.53 g/mol
Synonyms	14,15β-Epoxy-3β,14β,15α-trihydroxy-5β-bufa-20,22-dienolide; Bufalin derivative; 3β,14,15α-Trihydroxy-5β,14β-bufa-20,22-dienolide; 5β,14β-Bufa-20,22-dienolide-3β,14,15α-triol; Bufadienolide intermediate; Cardioactive steroid intermediate
EINECS	Contact for details

Quality Control

Our 3β,14,15α-Trihydroxy-5β,14β-Bufa-20,22-Dienolide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the high standards required for research and development. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.