Description

Tiamenidine CAS NO 31428-61-2 is a selective α-2 adrenergic receptor agonist, a key pharmaceutical intermediate in the synthesis of active pharmaceutical ingredients (APIs). This compound is valued for its precise pharmacological activity and high purity, which are critical for ensuring the efficacy and safety of the final drug product. It is primarily required by pharmaceutical manufacturers and research institutions engaged in the development and production of central nervous system (CNS) agents and antihypertensive medications.

Application

• Primary intermediate in the synthesis of Tiamenidine hydrochloride, the active pharmaceutical ingredient.
• Critical raw material for pharmaceutical R&D targeting α-2 adrenergic pathways.
• Used in the manufacture of prescription medications for hypertension and related cardiovascular conditions.
• Key component in process development and scale-up activities within API production.
• Reference standard in analytical laboratories for quality control and method validation.
• Building block for medicinal chemistry research exploring new CNS-active compounds.

Basic Information

Product Name	Tiamenidine
CAS No.	31428-61-2
Molecular Formula	C9H15ClN4S
Molecular Weight	246.76 g/mol
Synonyms	2-[(2-Chloro-4,5-dihydro-1H-imidazol-1-yl)methyl]-4,5-dihydrothiazole; 2-[(2-Chloro-4,5-dihydro-1H-imidazol-1-yl)methyl]-2-thiazoline; Tiamenidine base; Tiamenidine free base; 1-(2-Thiazolin-2-ylmethyl)-2-chloro-4,5-dihydroimidazole; B-HT 920; BHT 920
EINECS	Contact for details

Quality Control

Our Tiamenidine is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity, residual solvent analysis, and identification by IR and NMR spectroscopy, to ensure it meets the stringent requirements for pharmaceutical intermediates. Certificates of Analysis (COA) with full traceability are provided and can be tailored to meet specific customer or regulatory standards, including ICH guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after each use to minimize exposure to atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.5%
Related Substances (HPLC)	Total impurities ≤ 1.5% Any single impurity ≤ 0.5%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.