Description

2''-Deoxy-5-Iodouridine 3’,5’-Bis(4-Methylbenzoate) is a key protected nucleoside derivative, specifically a 5-iodo-2'-deoxyuridine analog with its 3' and 5' hydroxyl groups esterified with p-toluic acid. This chemical modification is crucial for enhancing stability, altering solubility, and serving as a versatile synthetic intermediate in advanced organic and medicinal chemistry. It is primarily required by research institutions and pharmaceutical development companies engaged in nucleoside chemistry, antiviral drug discovery, and the synthesis of radiolabeled probes for diagnostic applications.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the synthesis of novel antiviral and anticancer nucleoside analogs.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to develop modified nucleosides with enhanced therapeutic properties.
• Radiolabeling Precursor: Acts as a precursor for the synthesis of iodine-125 (125I) labeled compounds used in radioimmunoassays and molecular imaging.
• Biochemical Probe Development: Utilized in creating modified nucleotides to study DNA/RNA metabolism and enzyme mechanisms.
• Organic Synthesis: Employed in multi-step synthetic routes where protected sugar moieties are required for selective chemical transformations.

Basic Information

Product Name	2''-Deoxy-5-Iodouridine 3’,5’-Bis(4-Methylbenzoate)
CAS No.	31356-86-2
Molecular Formula	C26H23IN2O8
Molecular Weight	642.38 g/mol
Synonyms	5-Iodo-2'-deoxyuridine 3',5'-di-p-toluate; 5-Iodo-2'-deoxyuridine 3',5'-bis(4-methylbenzoate); IDU 3',5'-Di-p-toluate; 1-[(2R,4S,5R)-4-Hydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-iodopyrimidine-2,4-dione 3',5'-bis(4-methylbenzoate); 2'-Deoxy-5-iodouridine 3',5'-dip-toluate; 5-Iododeoxyuridine 3',5'-Di-p-toluoyl Ester
EINECS	Contact for details

Quality Control

Our 2''-Deoxy-5-Iodouridine 3’,5’-Bis(4-Methylbenzoate) is manufactured under strict quality protocols. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) detailing batch-specific results are available upon request to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). The compound is light-sensitive (store away from light). For long-term storage, consider storing under inert atmosphere to prevent potential degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.