Description

Tipepidine Hibenzate CAS NO 31139-87-4 is a synthetic, non-narcotic antitussive agent belonging to the chemical class of quinuclidine derivatives. This compound is valued for its selective action on the central nervous system to suppress cough reflexes without significant sedative effects. It is a critical active pharmaceutical ingredient (API) primarily required by pharmaceutical manufacturers for the formulation of prescription and over-the-counter cough suppressants and cold medications.

Application

• Primary Pharmaceutical Ingredient: Core active component in antitussive syrups, tablets, and lozenges for dry, non-productive cough.
• Combination Cold & Flu Medications: Used in formulations combined with antihistamines, decongestants, or expectorants for multi-symptom relief.
• Pediatric and Adult Formulations: Serves as a key ingredient in age-appropriate dosage forms, requiring strict purity controls.
• Clinical Research & Development: Utilized as a reference standard and raw material in pharmacological studies and new drug development.
• Generic Drug Manufacturing: Essential for the production of bioequivalent generic versions of branded antitussive medications.
• Veterinary Pharmaceuticals: Applied in the development of cough suppressants for animal health applications.

Basic Information

Product Name	Tipepidine Hibenzate
CAS No.	31139-87-4
Molecular Formula	C21H25NO3S
Molecular Weight	371.50 g/mol
Synonyms	Tipepidine; Tipepidine Hibenzate; 3-(Di-2-thienylmethylene)-1-azabicyclo[2.2.2]octane Hibenzate; AS-8112; Antitux; Hibenzate salt of Tipepidine; Tipepidine hydrogen benzilate; Tipepidine Hydroxybenzilate
EINECS	Contact for details

Quality Control

Our Tipepidine Hibenzate is manufactured under strict quality management systems to meet the rigorous standards of the pharmaceutical industry. Each batch is subjected to comprehensive analytical testing, including identity confirmation, purity assay, and impurity profiling, to ensure compliance with in-house specifications and relevant pharmacopeial guidelines. A Certificate of Analysis (COA) detailing all test results is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from incompatible materials. The container must be kept tightly closed to protect the hygroscopic material from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 1.0% Any single impurity ≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.