Description

n-(Triphenylmethyl)-2'-O,5'-o-Bis(Triphenylmethyl)Adenosine is a sophisticated, multi-protected adenosine derivative, a crucial intermediate in oligonucleotide synthesis and nucleoside chemistry. Its primary value lies in providing selective protection for the 2'- and 5'- hydroxyl groups of adenosine, enabling precise and efficient construction of complex nucleic acid sequences. This high-purity building block is essential for researchers and manufacturers in pharmaceutical development, particularly for antisense oligonucleotides, siRNA, and other therapeutic nucleic acids, as well as for advanced academic research in molecular biology and medicinal chemistry.

Application

• Oligonucleotide Synthesis: A critical phosphoramidite precursor for the solid-phase synthesis of DNA and RNA sequences, especially where 2'-O-protection is required.
• Antisense & siRNA Therapeutics: Serves as a key building block in the manufacture of therapeutic oligonucleotides targeting genetic diseases and cancers.
• Nucleoside Analogue Development: Used in the research and synthesis of modified nucleosides with potential antiviral or anticancer activity.
• Medicinal Chemistry Research: Enables the study of structure-activity relationships (SAR) by allowing specific modifications to the adenosine scaffold.
• Diagnostic Probe Synthesis: Employed in creating labeled nucleic acid probes for diagnostic assays and genomic research.
• Process Development: Used in scaling up and optimizing synthetic routes for nucleoside-based active pharmaceutical ingredients (APIs).

Basic Information

Product Name	n-(Triphenylmethyl)-2'-O,5'-o-Bis(Triphenylmethyl)Adenosine
CAS No.	31085-56-0
Molecular Formula	C58H49N5O4
Molecular Weight	888.04 g/mol
Synonyms	2',5'-Di-O-trityl-N-trityladenosine; N,2',5'-Tris(trityl)adenosine; N-Trityl-2',5'-di-O-trityladenosine; Adenosine, N,2',5'-tris(triphenylmethyl)-; 6-N-Trityl-2',5'-di-O-trityladenosine; Trt-Ado(Trt)2; Fully Tritylated Adenosine; 31085-56-0
EINECS	Contact for details

Quality Control

Our n-(Triphenylmethyl)-2'-O,5'-o-Bis(Triphenylmethyl)Adenosine is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity, critical for sensitive synthetic applications. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP principles where applicable, and our quality commitment ensures the material meets the exacting standards required for pharmaceutical research and development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions, such as in a glovebox or under an inert atmosphere (argon/nitrogen), to maintain stability and purity. Keep the container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Assay (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.