Description

[5-(6-Aminopurin-9-Yl)-3,4-Dihydroxy-Oxolan-2-Yl]Methoxyphosphonic Acid is a high-purity nucleoside phosphonate derivative of significant interest in advanced biochemical research and pharmaceutical development. This compound serves as a critical building block and a potent inhibitor for studying nucleotide metabolism and enzyme function. It is essential for researchers and manufacturers in the fields of antiviral drug discovery, molecular biology, and diagnostic assay development.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel antiviral and anticancer nucleotide analogs.
• Biochemical Research: Used as a substrate or inhibitor for studying enzymes like polymerases, kinases, and phosphodiesterases.
• Diagnostic Reagent Development: Employed in the formulation of high-sensitivity kits for molecular diagnostics and enzymatic assays.
• Life Science Tools: A component in specialized cell culture media and buffers for probing cellular nucleotide pathways.
• Academic Research: Fundamental studies in medicinal chemistry, enzymology, and metabolic pathway analysis.

Basic Information

Product Name	[5-(6-Aminopurin-9-Yl)-3,4-Dihydroxy-Oxolan-2-Yl]Methoxyphosphonic Acid
CAS No.	31077-38-0
Molecular Formula	C10H14N5O7P
Molecular Weight	347.22 g/mol
Synonyms	9-[(2R,3S,4R,5R)-3,4-Dihydroxy-5-(phosphonomethoxy)oxolan-2-yl]purin-6-amine; 9-[(2R,3S,4R,5R)-3,4-Dihydroxy-5-(phosphonomethoxy)tetrahydrofuran-2-yl]-9H-purin-6-amine; PMEA Nucleotide; Adefovir Nucleotide; GS-3933 Nucleotide; (R)-PMPA Nucleotide Analog; 9-[2-(Phosphonomethoxy)ethyl]adenine Nucleotide Form
EINECS	Contact for details

Quality Control

Our [5-(6-Aminopurin-9-Yl)-3,4-Dihydroxy-Oxolan-2-Yl]Methoxyphosphonic Acid is manufactured under strict quality systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability, consistency, and compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 95.0%
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.