Description

Amphotericin B is a potent polyene macrolide antifungal antibiotic derived from *Streptomyces nodosus*. It is a critical pharmaceutical active ingredient valued for its broad-spectrum activity against severe systemic fungal and protozoal infections. This high-purity compound is essential for manufacturers in the pharmaceutical and biotechnology sectors, particularly for formulating injectable and topical antifungal medications.

Application

• Pharmaceutical API: Primary active ingredient in antifungal injections, creams, and ointments for treating systemic mycoses, leishmaniasis, and other severe infections.
• Hospital & Clinical Formulations: Used in compounding pharmacies and hospital settings for preparing specialized antifungal treatments.
• Biomedical Research: A vital tool in microbiology and cell biology laboratories for studying fungal cell membrane structure and function, and for selective pressure in cell culture.
• Veterinary Medicine: Employed in antifungal preparations for treating serious fungal infections in animals.
• Reference Standard: Serves as a high-purity analytical standard for quality control and assay development in pharmaceutical testing laboratories.

Basic Information

Item	Detail
Product Name	Amphotericin B
CAS No.	30652-87-0
Molecular Formula	C47H73NO17
Molecular Weight	924.09 g/mol
Synonyms	Amphotericin; Amphotericin B, USP; Amphotericin B from *Streptomyces nodosus*; Ampho B; Fungilin; Fungizone; Amphomoronal; 1,3,5,7,9,11,13,15,17,37,39,41,43,45,47-Pentadecahydroxy-18-methyl-20,22,24,26,28,30,32,34,36-nonahydroxy-19-oxo-16,40-di(1-oxopropoxy)-17,39-dioxa-16-azanonacyclo[36.14.2.23,6.28,11.214,18.221,24.227,30.233,36]heptatetraconta-3,5,8,10,14,21,23,27,29,33,35,38,41,43,45-pentadecaene-37-carboxylic acid
EINECS	250-264-3

Quality Control

Our Amphotericin B is manufactured under strict quality management systems. It undergoes comprehensive analytical testing, including HPLC for purity and potency, to meet or exceed relevant pharmacopeial standards such as USP and EP. A detailed Certificate of Analysis (COA) is provided with each batch, confirming identity, purity, and specific impurity profiles to ensure suitability for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or refrigerated (2-8°C) as specified. This product is hygroscopic (moisture-sensitive) and should be stored under dry, inert conditions to prevent degradation. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	Yellow to orange powder
Identification (IR)	Conforms to standard
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 95.0% (on dried basis)
Loss on Drying	≤ 5.0 %
Specific Rotation	+333° to +355° (c=0.5, DMF)
Heavy Metals	≤ 20 ppm
Residual Solvents	Complies with ICH guidelines
Bacterial Endotoxins	< 5.0 EU/mg (for injectable grade)
Microbial Enumeration	Complies with EP/USP

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.