Description

8-(Methylthio)Cyclic 3',5'-Adenosine Monophosphate is a chemically modified analog of cyclic adenosine monophosphate (cAMP), a crucial secondary messenger in cellular signal transduction. This thioether derivative is valued for its enhanced membrane permeability and resistance to phosphodiesterase hydrolysis, making it a potent tool for modulating intracellular cAMP levels. It is primarily utilized by researchers and developers in the pharmaceutical and biotechnology sectors for investigating cell signaling pathways, drug discovery, and as a reference standard.

Application

• Biochemical Research: As a cell-permeable cAMP analog to study and manipulate intracellular signaling cascades, protein kinase A (PKA) activation, and gene expression regulation.
• Pharmaceutical R&D: Serving as a key intermediate or reference standard in the development of therapeutics targeting G-protein-coupled receptors (GPCRs) and metabolic disorders.
• Cell Biology Studies: Used to investigate the role of cAMP in processes such as cell differentiation, proliferation, and apoptosis in various cell lines.
• Enzyme Inhibition Studies: Acting as a stable, hydrolysis-resistant substrate analog for studying phosphodiesterase (PDE) enzyme kinetics and inhibitor screening.
• Diagnostic Reagent Manufacturing: Potential use as a component in assay kits for detecting and quantifying cAMP-related biological activities.

Basic Information

Product Name	8-(Methylthio)Cyclic 3',5'-Adenosine Monophosphate
CAS No.	30630-07-0
Molecular Formula	C11H14N5O6PS
Molecular Weight	375.30 g/mol
Synonyms	8-(Methylthio)-cAMP; 8-Methylthioadenosine 3',5'-cyclic monophosphate; 8-MT-cAMP; 8-(Methylmercapto)cyclic adenosine monophosphate; 8-(Methylsulfanyl)adenosine 3',5'-cyclic phosphate; 8-SCH3-cAMP; 8-Methylthio-cyclic AMP; 8-(Methylthio)adenosine cyclic 3',5'-(hydrogen phosphate)
EINECS	Contact for details

Quality Control

Our 8-(Methylthio)Cyclic 3',5'-Adenosine Monophosphate is produced under stringent quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and tests for residual solvents and moisture content. We provide a detailed Certificate of Analysis (COA) with every shipment to ensure traceability and compliance with your research or development specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the container to reach room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Solubility	Soluble in water, DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.