Description

5-(Hydroxymethyl)Uridine is a modified nucleoside featuring a hydroxymethyl group at the 5-position of the uracil base. This structural modification makes it a valuable building block and intermediate in the synthesis of more complex nucleoside analogs and oligonucleotides. It is primarily utilized by research institutions and manufacturers in the pharmaceutical, biotechnology, and life science sectors for applications in drug discovery, nucleic acid research, and the development of diagnostic tools.

Application

• Pharmaceutical Intermediate: A key synthon for the production of novel antiviral and anticancer nucleoside drugs.
• Oligonucleotide Synthesis: Serves as a modified monomer in the solid-phase synthesis of research-grade and therapeutic oligonucleotides.
• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies to investigate nucleic acid metabolism and repair pathways.
• Proteomics & Genomics: Employed in the development of cross-linking agents, probes, and tools for studying RNA structure and protein-RNA interactions.
• Diagnostic Reagent Manufacturing: Incorporated into the design of molecular probes and primers for PCR and other diagnostic assays.
• Academic Research: Fundamental studies in medicinal chemistry and chemical biology exploring the structure-activity relationships of nucleosides.

Basic Information

Product Name	5-(Hydroxymethyl)Uridine
CAS No.	30414-00-7
Molecular Formula	C10H14N2O7
Molecular Weight	274.23 g/mol
Synonyms	5-Hydroxymethyluridine; 5-(Hydroxymethyl)-1-β-D-ribofuranosyluracil; 1-((2R,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-(hydroxymethyl)pyrimidine-2,4(1H,3H)-dione; 5-HMU; Uridine, 5-(hydroxymethyl)-
EINECS	Contact for details

Quality Control

Our 5-(Hydroxymethyl)Uridine is produced under a strict quality management system. Each batch undergoes comprehensive analytical testing including HPLC for purity, NMR and MS for structural confirmation, and tests for residual solvents and moisture. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to ensure traceability and compliance with your research or cGMP starting material requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.