Description

n-Methoxy-n-Methylcarbamoyl Chloride CAS NO 30289-28-2 is a versatile and highly reactive chemical intermediate, primarily used as a key building block in organic synthesis. Its core value lies in its ability to efficiently introduce the Weinreb amide moiety, a crucial functional group for the controlled synthesis of ketones from carboxylic acid derivatives. This compound is essential for research chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries who require high-purity intermediates for complex molecule construction.

Application

• Pharmaceutical Intermediate: A critical reagent in the synthesis of active pharmaceutical ingredients (APIs), particularly for constructing ketone functionalities via Weinreb amide chemistry.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides where specific amide linkages are required.
• Peptide Mimetics & Drug Discovery: Employed in medicinal chemistry for the preparation of peptide analogs and novel heterocyclic compounds during lead optimization.
• Material Science Precursor: Serves as a building block for specialized polymers and functional materials requiring specific amide or carbamate structures.
• Academic & R&D Laboratories: A valuable tool for methodological development and the synthesis of complex natural products or novel molecular architectures in research settings.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for scale-up and production under cGMP guidelines where applicable.

Basic Information

Product Name	n-Methoxy-n-Methylcarbamoyl Chloride
CAS No.	30289-28-2
Molecular Formula	C4H8ClNO2
Molecular Weight	137.56 g/mol
Synonyms	N-Methoxy-N-methylcarbamoyl Chloride; N-Methoxy-N-methylcarbamic Acid Chloride; N-Methoxy-N-methylchloroformamide; N-Methyl-N-methoxycarbamoyl Chloride; Weinreb Chloride; Weinreb's Reagent Chloride; MOC-Cl; (Methoxy(methyl)carbamoyl) Chloride
EINECS	Contact for details

Quality Control

Our n-Methoxy-n-Methylcarbamoyl Chloride is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity, suitable for demanding synthetic applications. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing key parameters such as assay, identity, and impurity profiles. Our quality management system is designed to meet the rigorous standards required by our global customer base in advanced chemical synthesis.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, containers must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent decomposition. Keep away from strong acids, bases, and oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Impurities (HPLC)	≤ 1.0% (total)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.