Description

8-Aminoadenosine is a chemically modified nucleoside derivative of adenosine, featuring an amino group substitution at the 8-position of the purine ring. This structural modification makes it a valuable intermediate and building block in the synthesis of novel nucleoside analogs and pharmaceutical candidates. It is primarily utilized by research institutions and pharmaceutical companies engaged in medicinal chemistry, biochemistry, and molecular biology. The compound, identified by CAS number 3868-33-5, is essential for developing potential therapeutic agents targeting various biological pathways.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of novel antiviral and anticancer nucleoside analogs.
• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies to understand adenosine deaminase and other nucleoside-metabolizing enzymes.
• Medicinal Chemistry: A crucial building block for structure-activity relationship (SAR) studies to optimize drug potency and selectivity.
• Probe Development: Utilized in the creation of fluorescent or affinity-labeled probes for studying adenosine receptor interactions and cellular signaling.
• Nucleic Acid Chemistry: Employed in the synthesis of modified oligonucleotides for diagnostic and research applications.
• Reference Standard: Acts as a high-purity analytical standard for quality control and method development in pharmaceutical analysis.

Basic Information

Product Name	8-Aminoadenosine
CAS No.	3868-33-5
Molecular Formula	C10H14N6O4
Molecular Weight	282.26 g/mol
Synonyms	8-Amino-9-β-D-ribofuranosyl-9H-purin-6-amine; 8-Amino-9-β-D-ribofuranosyladenine; 8-Aminoadenosine; 8-Amino-adenosine; Adenosine, 8-amino-; 9H-Purin-6-amine, 8-amino-9-β-D-ribofuranosyl-
EINECS	223-389-9

Quality Control

Our 8-Aminoadenosine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and tests for residual solvents and moisture content. We provide Certificates of Analysis (COA) with every shipment, detailing all specifications and test results to ensure traceability and compliance with your research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after each use to prevent moisture absorption, which may affect stability and purity. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.