Description

2',3'-Isopropylidene-2,5'-Anhydrouridine is a key protected nucleoside derivative and a vital synthetic intermediate in organic chemistry. This compound matters for its role in constructing complex nucleoside analogs with high regioselectivity and yield. It is primarily needed by pharmaceutical R&D teams and fine chemical manufacturers engaged in the synthesis of antiviral agents, modified oligonucleotides, and other bioactive molecules.

Application

• Pharmaceutical Intermediate: Critical building block for the synthesis of novel antiviral and anticancer nucleoside analogs.
• Oligonucleotide Chemistry: Used in the preparation of modified RNA/DNA monomers for research and therapeutic applications.
• Glycosylation Studies: Serves as a substrate or intermediate in studies of nucleoside sugar chemistry and enzymatic transformations.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies to develop new therapeutic candidates.
• Process Chemistry: Utilized in the scalable production of advanced intermediates for Active Pharmaceutical Ingredients (APIs).
• Bioconjugation: Acts as a starting material for creating labeled or tagged nucleosides used in diagnostics and probes.

Basic Information

Product Name	2',3'-Isopropylidene-2,5'-Anhydrouridine
CAS No.	3868-21-1
Molecular Formula	C₁₂H₁₄N₂O₅
Molecular Weight	266.25 g/mol
Synonyms	2,5'-Anhydro-2',3'-O-isopropylideneuridine; 2,2'-Anhydro-1-(2,3-O-isopropylidene-β-D-ribofuranosyl)uracil; 2,5'-Anhydro-2',3'-O-(1-methylethylidene)uridine; 2',3'-O-Isopropylidene-2,5'-anhydrouridine; Uridine, 2,5'-anhydro-2',3'-O-(1-methylethylidene)-; 2,5'-Anhydro-2',3'-O-(1-methylethylidene)uridine
EINECS	223-389-5

Quality Control

Our 2',3'-Isopropylidene-2,5'-Anhydrouridine is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the high standards required for pharmaceutical research and synthesis. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.