Description

2',3'-o-Isopropylidene-5-Hydroxymethyl Uridine is a key protected nucleoside intermediate, essential for the synthesis of modified RNA and DNA analogs. This compound provides a critical building block for researchers and manufacturers developing advanced oligonucleotide therapeutics, diagnostics, and research tools. It is primarily utilized by pharmaceutical R&D teams, biotechnology companies, and fine chemical suppliers focused on nucleoside chemistry and nucleic acid synthesis.

Application

• Oligonucleotide Synthesis: A vital intermediate for the solid-phase and solution-phase synthesis of modified RNA and DNA strands.
• Antiviral & Anticancer Prodrug Development: Used in the research and production of nucleoside-based prodrugs and active pharmaceutical ingredients (APIs).
• siRNA and mRNA Therapeutics: Serves as a precursor for introducing specific modifications into therapeutic oligonucleotides to enhance stability and efficacy.
• Diagnostic Probe Manufacturing: Employed in creating labeled nucleosides for fluorescent or radioactive probes used in molecular diagnostics.
• Biochemical Research: A valuable tool for studying enzyme mechanisms, nucleic acid structure, and function in academic and industrial laboratories.
• Fine Chemical Intermediate: Used in multi-step organic syntheses to create more complex, high-value nucleoside derivatives.

Basic Information

Product Name	2',3'-o-Isopropylidene-5-Hydroxymethyl Uridine
CAS No.	3816-77-1
Molecular Formula	C13H18N2O7
Molecular Weight	314.29 g/mol
Synonyms	5-Hydroxymethyl-2',3'-O-isopropylideneuridine; 5-(Hydroxymethyl)-2',3'-O-(1-methylethylidene)uridine; 2',3'-O-Isopropylidene-5-(hydroxymethyl)uridine; 5-(Hydroxymethyl)-2',3'-O-isopropylideneuridine; 2',3'-O-(1-Methylethylidene)-5-(hydroxymethyl)uridine; Uridine, 2',3'-O-(1-methylethylidene)-5-(hydroxymethyl)-; 5-HMU (protected)
EINECS	223-300-4

Quality Control

Our 2',3'-o-Isopropylidene-5-Hydroxymethyl Uridine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by NMR and IR spectroscopy, to ensure it meets the high standards required for pharmaceutical and research applications. Certificates of Analysis (COA) detailing all specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.