Description

Todralazine Hydrochloride is a high-purity pharmaceutical intermediate and active pharmaceutical ingredient (API). This compound is critical for research and development in cardiovascular pharmacology due to its specific biological activity. It is primarily utilized by pharmaceutical manufacturers, contract research organizations (CROs), and academic institutions engaged in drug discovery and synthesis.

Application

• Pharmaceutical API Synthesis: Serves as a key building block in the manufacture of antihypertensive medications.
• Pharmacological Research: Used in preclinical and clinical studies to investigate mechanisms of vasodilation and blood pressure regulation.
• Reference Standard: Employed as a certified reference material (CRM) in analytical laboratories for quality control and method validation.
• Process Development: Utilized in scaling up and optimizing synthetic routes for new chemical entities (NCEs).
• Academic Research: A reagent for biochemical studies and educational purposes in medicinal chemistry programs.

Basic Information

Product Name	Todralazine Hydrochloride
CAS No.	3778-76-5
Molecular Formula	C13H17N5·HCl
Molecular Weight	279.77 g/mol
Synonyms	1-Hydrazinophthalazine Hydrochloride; 2-Hydrazino-1-phthalazine Hydrochloride; BAY a 1040; EC 1; Todralazine HCl; 1(2H)-Phthalazinone, 2-hydrozinyl-, monohydrochloride; 2-Hydrazinophthalazine Monohydrochloride
EINECS	223-247-6

Quality Control

Our Todralazine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including identification, purity assay, and impurity profiling, to ensure it meets stringent specifications for pharmaceutical use. A Certificate of Analysis (COA) detailing all test results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). The product is hygroscopic (moisture-sensitive) and should be handled under appropriate conditions to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.