Description

1H-Pyrrole-2-Acetyl Chloride, α-Oxo- (9Ci) is a highly reactive acid chloride derivative of pyrrole, serving as a critical building block for the synthesis of complex heterocyclic compounds. Its core value lies in enabling the efficient introduction of the 2-acetylpyrrole moiety into target molecules, facilitating advanced research and development. This intermediate is essential for pharmaceutical chemists and agrochemical researchers working on novel active ingredients, particularly in medicinal chemistry for drug discovery programs.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of potential drug candidates, especially those targeting neurological disorders or possessing antimicrobial activity.
• Agrochemical Synthesis: Building block for developing novel pesticides and herbicides with heterocyclic core structures.
• Material Science Research: Used in the creation of advanced organic materials, such as conductive polymers or organic semiconductors based on pyrrole units.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes for studying biological processes and enzyme inhibition.
• Complex Ligand Synthesis: Intermediate for preparing specialized ligands used in catalysis and coordination chemistry.

Basic Information

Product Name	1H-Pyrrole-2-Acetyl Chloride, α-Oxo- (9Ci)
CAS No.	3768-70-5
Molecular Formula	C6H4ClNO2
Molecular Weight	157.55 g/mol
Synonyms	2-Acetylpyrrole-1-carbonyl Chloride; 2-Acetyl-1H-pyrrole-1-carbonyl Chloride; 1-(Chlorocarbonyl)-2-acetylpyrrole; α-Oxo-1H-pyrrole-2-acetyl Chloride; Pyrrole-2-carbonyl Chloride, 1-Acetyl-; 2-Acetylpyrrole-1-carboxylic Acid Chloride
EINECS	Contact for details

Quality Control

Every batch of 1H-Pyrrole-2-Acetyl Chloride, α-Oxo- is produced and tested under strict quality management protocols to ensure consistency and reliability for your synthetic workflows. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as purity, identity, and impurity profiles. Our quality systems are designed to support cGMP and ISO standards for advanced chemical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic and moisture-sensitive nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.