Description

N-Trimethylsilylaniline is a versatile organosilicon reagent featuring a silyl-protected aniline group. This compound is highly valued for its role as a key synthetic intermediate and protecting group in advanced organic synthesis, particularly for sensitive amine functionalities. It is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries who require high-purity building blocks for complex molecule assembly.

Application

• Pharmaceutical Intermediate: A crucial building block in the synthesis of active pharmaceutical ingredients (APIs), especially where protection of the aniline nitrogen is required.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides that incorporate aniline-derived structures.
• Silylating Agent: Functions as a reagent for introducing the trimethylsilyl (TMS) group onto other molecules, modifying their reactivity or physical properties.
• Material Science Precursor: Serves as a monomer or modifier in the development of specialized silicon-based polymers and advanced materials.
• Organic Synthesis Reagent: Employed in various name reactions and multi-step syntheses where a protected aniline is needed to control regioselectivity.
• Research & Development: A valuable tool for medicinal chemistry and process chemistry research in academic and industrial laboratories.

Basic Information

Product Name	N-Trimethylsilylaniline
CAS No.	3768-55-6
Molecular Formula	C9H15NSi
Molecular Weight	165.31 g/mol
Synonyms	N-(Trimethylsilyl)aniline; Anilinotrimethylsilane; (Phenylamino)trimethylsilane; N-Phenyltrimethylsilylamine; N-TMS-aniline; Trimethyl(phenylamino)silane; N-(Trimethylsilyl)benzenamine; TMS-Aniline
EINECS	223-193-9

Quality Control

Our N-Trimethylsilylaniline is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including GC, HPLC, and NMR, to ensure high chemical purity and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all relevant specifications. Our quality systems are designed to meet the stringent requirements of cGMP and ISO standards for fine chemical manufacturing.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Refractive Index (n20D)	1.5180 - 1.5220
Density (g/mL, 20°C)	0.910 - 0.920

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.