Description

1-Naphthyl Chloroformate is a specialized organic reagent belonging to the class of chloroformate esters. This compound is a critical building block in synthetic organic chemistry, primarily valued for its role as an efficient coupling agent and protecting group intermediate. It is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors who require high-purity intermediates for complex synthesis. Our supply ensures consistent quality and reliable availability for your most demanding R&D and production needs.

Application

• Pharmaceutical Intermediate: Key reagent in the synthesis of active pharmaceutical ingredients (APIs), particularly for carbamate prodrugs and polymer conjugates.
• Peptide Synthesis: Used as a coupling agent for the introduction of the naphthyloxycarbonyl (Noc) protecting group in solid-phase and solution-phase peptide chemistry.
• Polymer Chemistry: Serves as a functional monomer or chain modifier in the production of specialty polycarbonates and polyurethanes with tailored properties.
• Agrochemical Synthesis: Intermediate in the manufacture of certain herbicides and plant growth regulators requiring naphthalene-based structures.
• Chemical Derivatization: Employed to derivative alcohols and amines for analytical purposes, such as in chromatography for enhanced detection.
• Material Science Research: Used in surface functionalization and the creation of novel organic frameworks and dendritic structures.

Basic Information

Product Name	1-Naphthyl Chloroformate
CAS No.	3759-61-3
Molecular Formula	C11H7ClO2
Molecular Weight	206.62 g/mol
Synonyms	1-Naphthyl Chloroformate; 1-Naphthyloxycarbonyl Chloride; α-Naphthyl Chloroformate; Naphthalen-1-yl Carbonochloridate; 1-Naphthol Chloroformate; Noc-Cl; 1-NOC-Cl; Carbonochloridic Acid 1-Naphthyl Ester
EINECS	223-164-8

Quality Control

Every batch of our 1-Naphthyl Chloroformate is manufactured and tested under a strict quality management system. We ensure compliance with relevant industry standards for fine chemicals. Comprehensive testing includes identity confirmation, purity assay, and impurity profiling. A detailed Certificate of Analysis (COA) documenting all test results is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its moisture-sensitive (hygroscopic) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening. Recommended storage temperature is 2-8°C for long-term stability.

Specification

Item	Specification
Appearance	White to off-white crystalline solid or powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.