Description

Coumarin-3-Carboxylic Acid Chloride is a versatile and highly reactive chemical intermediate derived from the coumarin scaffold. This compound is valued for its role as a key building block in the synthesis of more complex heterocyclic and fluorescent molecules. It is primarily sought after by research institutions and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries for developing new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of novel drug candidates, particularly those targeting various enzyme inhibitors and receptor modulators.
• Fluorescent Probe Synthesis: Used to create advanced fluorescent dyes and molecular probes for bioimaging, diagnostics, and sensor applications.
• Agrochemical Development: Serves as a building block for creating new pesticides and herbicides with specific modes of action.
• Polymer & Material Science: Incorporated into polymers to impart specific optical or chemical properties, useful in advanced coatings and functional materials.
• Organic Synthesis & Research: Employed in academic and industrial R&D for constructing complex coumarin derivatives and exploring new chemical reactions.
• Peptide & Bioconjugate Chemistry: Acts as an acylating agent for coupling reactions to label biomolecules or modify peptides.

Basic Information

Product Name	Coumarin-3-Carboxylic Acid Chloride
CAS No.	3757-06-0
Molecular Formula	C10H5ClO3
Molecular Weight	208.60 g/mol
Synonyms	3-Coumarincarbonyl Chloride; Coumarin-3-Carbonyl Chloride; 2-Oxo-2H-chromene-3-carbonyl chloride; 2-Oxo-2H-1-benzopyran-3-carbonyl chloride; 3-Chlorocarbonylcoumarin; 3-Carboxycoumarin acid chloride; 2H-1-Benzopyran-2-one, 3-(chlorocarbonyl)-
EINECS	223-158-7

Quality Control

Our Coumarin-3-Carboxylic Acid Chloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and IR spectroscopy, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic and moisture-sensitive nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent decomposition.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.