Description

1,3-Thiazole-4-Carbonyl Chloride is a versatile and highly reactive organic intermediate, specifically an acyl chloride derivative of the thiazole heterocycle. Its primary value lies in its role as a key building block for the synthesis of more complex molecules, enabling the introduction of the thiazole-4-carbonyl moiety. This compound is essential for research chemists and process development scientists in the pharmaceutical and agrochemical industries. It is particularly sought after for the development of novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of active pharmaceutical ingredients (APIs), especially for molecules containing the thiazole pharmacophore.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides.
• Ligand and Catalyst Development: Serves as a starting material for creating novel ligands and organocatalysts used in asymmetric synthesis.
• Material Science Research: Employed in the development of specialty polymers, dyes, and functional materials with specific electronic properties.
• Bioconjugation and Probe Synthesis: Useful for modifying peptides, proteins, or other biomolecules to create diagnostic probes or study biological interactions.

Basic Information

Product Name	1,3-Thiazole-4-Carbonyl Chloride
CAS No.	3745-79-7
Molecular Formula	C4H2ClNOS
Molecular Weight	147.58 g/mol
Synonyms	4-Thiazolecarbonyl chloride; Thiazole-4-carbonyl chloride; 4-Carboxythiazole chloride; 1,3-Thiazole-4-carboxylic acid chloride; 4-Thiazolylcarbonyl chloride; Isothiazole-4-carbonyl chloride (common misnomer); T4CC; 3745-79-7
EINECS	223-148-4

Quality Control

Our 1,3-Thiazole-4-Carbonyl Chloride is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via IR and NMR spectroscopy, to ensure it meets the high standards required for research and industrial synthesis. A detailed Certificate of Analysis (COA) is provided with every shipment, guaranteeing traceability, consistency, and reliability for your critical processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic and moisture-sensitive nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent decomposition. Keep away from heat, sparks, open flames, and incompatible materials such as strong bases, alcohols, and amines.

Specification

Item	Specification
Appearance	White to off-white crystalline solid or powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.