Description

5-Iodo-2'-Deoxyuridine Triphosphate (CAS NO 3731-55-3) is a halogenated deoxyribonucleoside triphosphate analog that serves as a critical biochemical tool in molecular biology research. Its primary value lies in its ability to act as a chain terminator and substrate analog in enzymatic studies, particularly for DNA polymerases. This compound is essential for researchers and manufacturers in the fields of molecular diagnostics, virology, and anticancer drug development, where precise nucleotide manipulation is required.

Application

• Molecular Biology Research: Used as a substrate for DNA polymerases in enzymatic assays and studies of polymerase fidelity and mechanism.
• Antiviral & Anticancer Studies: Serves as a key intermediate or probe in the research and development of nucleoside analog-based therapeutics targeting viral replication and cancer cell proliferation.
• DNA Sequencing & Labeling: Employed in specialized sequencing techniques and as a potential precursor for the incorporation of iodine labels into nucleic acids for detection and imaging.
• Biochemical Reagent: Acts as a high-purity standard and reference material in analytical laboratories for quality control of related pharmaceutical compounds.
• Enzyme Kinetics: Utilized to investigate the kinetics and inhibition profiles of viral and cellular polymerases.

Basic Information

Product Name	5-Iodo-2'-Deoxyuridine Triphosphate
CAS No.	3731-55-3
Molecular Formula	C10H13N2O14P3I
Molecular Weight	628.0 g/mol
Synonyms	5-Iodo-2'-deoxyuridine 5'-triphosphate; Idoxuridine triphosphate; 5-Iodo-dUTP; IUdR triphosphate; 1-[(2R,4S,5R)-4-Hydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-iodo-1,2,3,4-tetrahydropyrimidine-2,4-dione 5'-(trihydrogen triphosphate); 5-Iodo-2'-deoxyuridine-5'-triphosphate
EINECS	Contact for details

Quality Control

Our 5-Iodo-2'-Deoxyuridine Triphosphate is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency suitable for sensitive research applications. Each lot is analyzed using advanced chromatographic and spectroscopic techniques. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to support your quality assurance requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive) and light-sensitive. For long-term storage, it is recommended to keep the material desiccated and under inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder or solid
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Water Content (Karl Fischer)	≤ 3.0%
Solubility	Soluble in water, DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.