Description

3-Isocyanatopropanoylchloride is a versatile bifunctional reagent containing both a highly reactive isocyanate group and an acid chloride moiety. This dual functionality makes it a critical building block for the synthesis of complex molecules, enabling the introduction of urethane, urea, and amide linkages in a single step. It is primarily sought by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty polymer industries for constructing active pharmaceutical ingredients (APIs), advanced intermediates, and functional materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs) and prodrugs, particularly those requiring carbamate or urea linkages.
• Agrochemical Synthesis: Used in the production of herbicides, fungicides, and insecticides where its reactive groups facilitate the creation of novel bioactive compounds.
• Polymer Modification: Serves as a cross-linking agent or chain extender in polyurethane, polyurea, and specialty polymer systems to enhance material properties.
• Bioconjugation & Probe Synthesis: Employed in biochemical research to label proteins, peptides, and other biomolecules via reactions with amine or hydroxyl groups.
• Organic Synthesis Reagent: A valuable tool in academic and industrial R&D for constructing heterocycles, dendrimers, and other complex organic architectures.
• Surface Coating & Adhesive Formulations: Imparts durability and specific adhesion properties in high-performance coatings and adhesive formulations.

Basic Information

Product Name	3-Isocyanatopropanoylchloride
CAS No.	3729-19-9
Molecular Formula	C4H4ClNO2
Molecular Weight	133.53 g/mol
Synonyms	3-Isocyanatopropionyl Chloride; β-Isocyanatopropionyl Chloride; 3-Isocyanopropanoyl Chloride; Propionyl chloride, 3-isocyanato-; NSC 163081; Isocyanatoacetyl Chloride Homolog; 3-Isocyanatopropionic Acid Chloride
EINECS	223-082-8

Quality Control

Our 3-Isocyanatopropanoylchloride is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including assay by titration and impurity profiling by GC/HPLC, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and specific impurity limits is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at temperatures between 2°C and 8°C (refrigerated) or as specified on the label. Due to its moisture-sensitive (hygroscopic) nature, containers must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent hydrolysis and degradation. Keep away from strong acids, bases, and oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms
Assay (GC/Titration)	≥ 97.0%
Purity (HPLC/GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Chloride Content	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.