Description

5-Isothiazolecarbonyl Chloride (7Ci,8Ci,9Ci) is a high-purity, reactive chemical intermediate essential for advanced synthesis. This compound matters as a key building block for introducing the isothiazole moiety, a privileged heterocyclic structure, into target molecules. It is primarily needed by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: Critical for the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders, anti-infectives, and other therapeutic areas where the isothiazole ring is pharmacologically active.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides, herbicides, and fungicides, leveraging the bioactivity of the isothiazole scaffold.
• Material Science Research: Serves as a precursor for functional polymers, liquid crystals, and organic electronic materials requiring specific heterocyclic components.
• Chemical Biology & Proteomics: Employed as a reactive handle for bioconjugation and the development of activity-based probes to study enzyme function.
• Custom Synthesis & Contract Manufacturing: A vital starting material for fine chemical and CDMO (Contract Development and Manufacturing Organization) companies producing bespoke compounds for client projects.

Basic Information

Product Name	5-Isothiazolecarbonyl Chloride (7Ci,8Ci,9Ci)
CAS No.	3683-97-4
Molecular Formula	C4H2ClNOS
Molecular Weight	147.58 g/mol
Synonyms	5-Isothiazolecarbonyl chloride; Isothiazole-5-carbonyl chloride; 1,2-Thiazole-5-carbonyl chloride; 5-Carboxyisothiazole chloride; 5-Chlorocarbonylisothiazole; 7CI, 8CI, 9CI reference compound; NSC 163063
EINECS	Contact for details

Quality Control

Our 5-Isothiazolecarbonyl Chloride is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity, typically meeting standards suitable for research and process development. Every lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP principles where applicable to support our clients' regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent decomposition. Recommended storage temperature is 2-8°C for long-term stability.

Specification

Item	Specification
Appearance	White to off-white crystalline solid or powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.