Description

N2-Benzoyl-D-Guanosine is a specifically protected nucleoside derivative, a key building block in oligonucleotide synthesis and pharmaceutical research. Its primary value lies in enabling the precise construction of RNA and DNA analogs, which is critical for developing therapeutic agents and diagnostic tools. This high-purity intermediate is essential for researchers and manufacturers in the fields of antisense oligonucleotide (ASO) production, mRNA vaccine development, and medicinal chemistry.

Application

• Solid-Phase Oligonucleotide Synthesis (SPOS): As a protected phosphoramidite precursor for automated synthesis of RNA and DNA sequences.
• Antisense & siRNA Therapeutics: A critical raw material in the manufacturing of gene-silencing drugs and research oligonucleotides.
• Medicinal Chemistry & Drug Discovery: Used in the research and development of nucleoside-based antiviral and anticancer agents.
• Diagnostic Probe Development: Employed in the synthesis of labeled probes for genetic testing and molecular diagnostics.
• Biochemical Research: Serves as a substrate or intermediate in enzymatic studies and metabolic pathway investigations.
• Custom Oligonucleotide Services: A fundamental component for CROs and CDMOs offering custom oligo synthesis.

Basic Information

Product Name	N2-Benzoyl-D-Guanosine
CAS No.	3676-72-0
Molecular Formula	C17H17N5O6
Molecular Weight	387.35 g/mol
Synonyms	2'-Deoxy-N2-benzoylguanosine; D-Guanosine, N2-benzoyl-; 9-β-D-Ribofuranosyl-N2-benzoylguanine; N2-Benzoyl-2'-deoxyguanosine (common misnomer); Bz-dG (abbreviation); N2-Bz-Guanosine; Guanosine, N2-benzoyl-; 3676-72-0
EINECS	Contact for details

Quality Control

Our N2-Benzoyl-D-Guanosine is produced under stringent conditions to meet the exacting standards of pharmaceutical and biotech applications. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (IR, NMR). We provide full traceability and detailed Certificates of Analysis (COA) to ensure compliance with your research or cGMP manufacturing requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.