Description

5-Amino-1-[2,3-o-(1-Methylethylidene)-β-D-Ribofuranosyl]-1H-Imidazole-4-Carboxamide is a sophisticated nucleoside analogue building block of significant interest in advanced pharmaceutical research and development. This compound serves as a critical precursor in the synthesis of modified nucleosides and nucleotides, which are essential for exploring novel therapeutic mechanisms. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of antiviral agents, anticancer drugs, and other biologically active molecules that target nucleic acid metabolism.

Application

• Pharmaceutical Intermediate: A key synthetic precursor for the development of novel nucleoside-based antiviral and anticancer therapeutics.
• Biochemical Research: Used in enzymatic studies and as a substrate analog to investigate nucleotide metabolism and related biological pathways.
• Antiviral Drug Development: Serves as a building block for potential prodrugs targeting viral polymerases (e.g., for hepatitis or herpes viruses).
• Oncology Research: Employed in the synthesis of compounds designed to inhibit tumor cell proliferation by interfering with DNA/RNA synthesis.
• Proteomics & Genomics: Can be utilized in the preparation of labeled probes or modified oligonucleotides for diagnostic and research applications.
• Academic Research: Fundamental studies in medicinal chemistry and organic synthesis to explore new chemical entities and their biological activities.

Basic Information

Product Name	5-Amino-1-[2,3-o-(1-Methylethylidene)-β-D-Ribofuranosyl]-1H-Imidazole-4-Carboxamide
CAS No.	3676-69-5
Molecular Formula	C12H18N4O5
Molecular Weight	298.30 g/mol
Synonyms	5-Amino-1-(2,3-O-isopropylidene-β-D-ribofuranosyl)imidazole-4-carboxamide; 5-AICA Riboside Isopropylidene Derivative; AICAR Isopropylidene Derivative; Acadesine Isopropylidene Derivative; 5-Aminoimidazole-4-carboxamide-1-β-D-ribofuranoside 2',3'-O-isopropylidene; 5-Amino-1-(2,3-O-isopropylidene-β-D-ribofuranosyl)-1H-imidazole-4-carboxamide; 3676-69-5; AICAR 2',3'-O-isopropylidene
EINECS	Contact for details

Quality Control

Our 5-Amino-1-[2,3-o-(1-Methylethylidene)-β-D-Ribofuranosyl]-1H-Imidazole-4-Carboxamide is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency suitable for research and development. All products undergo rigorous analytical testing, including HPLC, NMR, and mass spectrometry. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with each shipment to support your quality assurance requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.