Description

2-Isoindolinecarbonyl Chloride (7Ci,8Ci) is a versatile and highly reactive acid chloride derivative of isoindoline, serving as a critical building block in advanced organic synthesis. Its primary value lies in its ability to efficiently introduce the isoindolinecarbonyl moiety, enabling the construction of complex molecular architectures with precision. This intermediate is essential for research chemists and process development scientists in the pharmaceutical and agrochemical industries, particularly for the synthesis of active pharmaceutical ingredients (APIs), novel heterocyclic compounds, and functional materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, especially those containing the isoindoline scaffold for central nervous system (CNS) and oncology targets.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and insecticides that require the incorporation of complex heterocyclic structures.
• Polymer Chemistry: Acts as a monomer or functionalization agent for creating specialty polymers with tailored properties, such as polyamides or polyimides.
• Material Science Research: Employed in the development of organic electronic materials, ligands for catalysis, and other functional organic materials.
• Peptide Mimetics & Conjugation: Useful for acylating amines in the creation of peptide analogs or for bioconjugation strategies in medicinal chemistry.
• Chemical Research & Development: A fundamental reagent for exploring new organic reactions and synthesizing complex, multi-ring heterocyclic compounds in academic and industrial R&D settings.

Basic Information

Product Name	2-Isoindolinecarbonyl Chloride (7Ci,8Ci)
CAS No.	3432-58-4
Molecular Formula	C9H8ClNO
Molecular Weight	181.62 g/mol
Synonyms	Isoindoline-2-carbonyl chloride; 2-Isoindolinecarboxylic acid chloride; 1,3-Dihydro-2H-isoindole-2-carbonyl chloride; 2-Carboxyisoindoline chloride; Isoindolinecarbonyl chloride; 2-Isoindolinecarbonyl chloride; 2H-Isoindole-2-carbonyl chloride, 1,3-dihydro-
EINECS	Contact for details

Quality Control

Every batch of 2-Isoindolinecarbonyl Chloride is manufactured and tested under a strict quality management system to ensure consistency and reliability for your synthetic processes. We provide comprehensive analytical data including HPLC purity, identity confirmation (IR, NMR), and impurity profiling. A Certificate of Analysis (COA) detailing all specifications and test results is available for each lot upon request, supporting your regulatory and quality assurance requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Due to its hygroscopic and moisture-sensitive nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent decomposition. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.