Description

3',5'-Dioctanoyl-5-Fluoro-2'-Deoxyuridine is a chemically modified nucleoside analog, specifically a prodrug derivative of the antiviral and antineoplastic agent 5-Fluoro-2'-deoxyuridine (Floxuridine). This compound matters for its enhanced lipophilicity and potential for improved cellular uptake and bioavailability compared to its parent molecule. It is primarily needed by pharmaceutical research and development teams, medicinal chemists, and manufacturers in the life sciences sector for the development of novel therapeutic agents targeting viral infections and cancer.

Application

• Pharmaceutical Intermediate: Serves as a key synthetic precursor in the research and development of novel nucleoside-based antiviral and anticancer prodrugs.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to optimize the pharmacokinetic properties, such as membrane permeability and metabolic stability, of fluoropyrimidine analogs.
• Biochemical Tool Compound: Employed in laboratory studies to investigate mechanisms of nucleoside metabolism, prodrug activation, and cellular resistance pathways.
• Antiviral Agent Development: Investigated for potential activity against DNA viruses, leveraging the mechanism of thymidylate synthase inhibition upon intracellular conversion to the active metabolite.
• Oncology Research: Explored in preclinical models for its cytotoxic effects on rapidly dividing cells, following enzymatic cleavage to release 5-Fluoro-2'-deoxyuridine.
• Prodrug Strategy Prototype: Acts as a model compound for designing lipophilic prodrugs aimed at improving the delivery and efficacy of polar nucleoside therapeutics.

Basic Information

Product Name	3',5'-Dioctanoyl-5-Fluoro-2'-Deoxyuridine
CAS No.	3415-70-1
Molecular Formula	C25H39FN2O8
Molecular Weight	514.59 g/mol
Synonyms	5-Fluoro-2'-deoxyuridine 3',5'-dioctanoate; Floxuridine Dioctanoate; 1-[(2R,4S,5R)-4-Hydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-fluoro-1,2,3,4-tetrahydropyrimidine-2,4-dione 3',5'-dioctanoate; 5-Fluoro-2'-deoxyuridine-3',5'-dioctanoyl ester; FDURD Octanoate; 3',5'-Di-O-octanoyl-5-fluoro-2'-deoxyuridine
EINECS	Contact for details

Quality Control

Our 3',5'-Dioctanoyl-5-Fluoro-2'-Deoxyuridine is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the high standards required for research and development applications. Certificates of Analysis (COA) detailing batch-specific results are available upon request to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after each use to prevent degradation from atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms to reference spectrum
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.