Description

Adenosine-5'-Carboxylic Acid is a chemically modified nucleoside derivative, serving as a crucial building block and intermediate in advanced organic synthesis. Its primary value lies in enabling the development of novel nucleotide analogs and prodrugs with potential therapeutic applications. This high-purity intermediate is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and life science sectors focused on nucleoside-based drug discovery and development.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel adenosine receptor agonists/antagonists and other nucleoside-based active pharmaceutical ingredients (APIs).
• Bioconjugation & Probe Development: Used to introduce carboxylic acid functionality for coupling reactions in the creation of labeled probes, diagnostics, and targeted drug delivery systems.
• Nucleotide Chemistry Research: Fundamental building block for academic and industrial research exploring modified nucleotide structures, metabolism, and signaling pathways.
• Prodrug Synthesis: Enables the design and synthesis of prodrugs by serving as a linker or modified nucleoside component to improve drug solubility, stability, or targeting.
• Biochemical Tool Compound: Employed in enzymatic studies and as a substrate analog to investigate the mechanisms of nucleoside-metabolizing enzymes.

Basic Information

Product Name	Adenosine-5'-Carboxylic Acid
CAS No.	3415-09-6
Molecular Formula	C11H13N5O6
Molecular Weight	311.25 g/mol
Synonyms	5'-Carboxyadenosine; Adenosine-5'-carboxylic acid; 9-β-D-Ribofuranosyl-9H-purin-6-amine-5'-carboxylic acid; 5'-Adenosinecarboxylic acid; 6-Amino-9-(5-carboxy-5-deoxy-β-D-ribofuranosyl)-9H-purine; 5'-COOH-Ado
EINECS	Contact for details

Quality Control

Our Adenosine-5'-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and tests for residual solvents and moisture. We provide Certificates of Analysis (COA) with each shipment to ensure traceability and compliance with your research or cGMP-grade requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This compound is hygroscopic (moisture-sensitive) and light-sensitive (store away from light). For long-term storage, consider desiccation and an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.