Description

5'-Thymidylic Acid Calcium Salt is the calcium salt form of thymidine monophosphate, a key nucleotide building block. This compound is essential for research and development in life sciences, offering a stable and bioavailable form of the nucleotide for various biochemical applications. It is primarily utilized by manufacturers and researchers in the pharmaceutical, biotechnology, and diagnostic reagent sectors for applications such as oligonucleotide synthesis, enzyme studies, and cell culture media supplementation.

Application

• Oligonucleotide Synthesis: Serves as a critical raw material (phosphoramidite precursor) in the solid-phase synthesis of DNA strands for research, diagnostics, and therapeutic development.
• Biochemical Research: Used as a substrate or standard in enzymatic assays, metabolic pathway studies, and nucleotide metabolism research.
• Cell Culture & Media Formulation: Incorporated into specialized cell culture media to support the growth of fastidious cell lines in biomanufacturing and virology.
• Diagnostic Reagent Production: Acts as a component in the formulation of kits for molecular diagnostics, PCR, and other nucleic acid amplification techniques.
• Pharmaceutical Intermediates: Employed as a building block in the research and development of nucleotide-based antiviral or anticancer prodrugs.
• Enzyme Cofactor Studies: Utilized in studies involving DNA polymerases, kinases, and other enzymes that interact with thymidine nucleotides.

Basic Information

Product Name	5'-Thymidylic Acid Calcium Salt
CAS No.	3372-09-6
Molecular Formula	C10H13CaN2O8P • xH2O
Molecular Weight	Anhydrous: 352.26 g/mol
Synonyms	Thymidine 5'-Monophosphate Calcium Salt; dTMP Calcium Salt; 5'-Thymidylic Acid Calcium; Calcium Thymidylate; Thymidine 5'-(dihydrogen phosphate) calcium salt; 2'-Deoxythymidine 5'-monophosphate calcium salt; TMP Calcium
EINECS	Contact for details

Quality Control

Our 5'-Thymidylic Acid Calcium Salt is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure high purity and consistency, meeting the stringent requirements for research and bioproduction. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to guarantee traceability and compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept in a desiccated environment to maintain stability. For long-term storage, consider conditions of 2-8°C.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 5.0%
pH (5% Solution)	6.0 - 8.0
Heavy Metals (as Pb)	≤ 10 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0%
Solubility	Soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.