Description

3-Methylcrotonoyl Chloride is a versatile and highly reactive acid chloride derivative of 3-methylcrotonic acid. This compound serves as a critical building block in organic synthesis, enabling the efficient introduction of the 3-methylcrotonoyl moiety into target molecules. It is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries who require a reliable, high-purity reagent for acylation and condensation reactions.

Application

• Pharmaceutical Intermediates: Key starting material for the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of protease inhibitors and other therapeutic agents.
• Agrochemical Synthesis: Used in the production of advanced pesticides, herbicides, and plant growth regulators.
• Peptide Chemistry: Employed as an acylating agent in peptide coupling reactions to modify amino acid side chains.
• Polymer Science: Acts as a monomer or cross-linking agent in the production of specialty polymers with tailored properties.
• Fine Chemical Production: Integral to the manufacture of flavors, fragrances, and advanced organic compounds.
• Research & Development: A valuable reagent in academic and industrial R&D labs for exploring new synthetic pathways and creating novel chemical entities.

Basic Information

Product Name	3-Methylcrotonoyl Chloride
CAS No.	3350-78-5
Molecular Formula	C5H7ClO
Molecular Weight	118.56 g/mol
Synonyms	3-Methylbut-2-enoyl chloride; 3,3-Dimethylacryloyl chloride; Isopentenoyl chloride; 3-Methylcrotonic acid chloride; 3-Methyl-2-butenoyl chloride; β,β-Dimethylacryloyl chloride; Senecic acid chloride
EINECS	222-111-8

Quality Control

Our 3-Methylcrotonoyl Chloride is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including GC, HPLC, and NMR, to ensure high purity and consistency. We provide detailed Certificates of Analysis (COA) with each shipment, confirming compliance with agreed specifications. Our quality commitment supports applications requiring reliable and traceable raw materials for GMP and non-GMP production.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area away from incompatible materials such as strong bases, alcohols, and oxidizing agents. Recommended storage temperature is 2-8°C for long-term stability. The container should be kept tightly sealed under an inert atmosphere (e.g., nitrogen) to minimize moisture absorption and degradation.

Specification

Item	Specification
Appearance	Clear, colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Acid Value	Contact for details
Density (at 20°C)	~1.08 g/cm³
Refractive Index (n20D)	~1.465

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.