Description

5-Pyrimidinecarbonyl Chloride, 1,2,3,4-Tetrahydro-2,4-Dioxo- (7Ci,8Ci,9Ci) is a highly reactive and versatile heterocyclic acid chloride derivative. This compound is a critical synthetic intermediate valued for its ability to introduce the pyrimidine-2,4-dione (uracil) scaffold into more complex molecules. It is primarily sought after by research chemists and process development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of uracil and cytosine analogs, which are core structures in antiviral and anticancer drug candidates.
• Agrochemical Synthesis: Used in the research and development of novel herbicides and plant growth regulators that target specific biochemical pathways.
• Organic Synthesis Reagent: Serves as an acylating agent in peptide coupling and other condensation reactions to form amide bonds with amines.
• Material Science Research: Potential monomer or precursor for creating specialized polymers with unique thermal or electronic properties.
• Bioconjugation Chemistry: Useful for labeling biomolecules (e.g., proteins, nucleotides) due to its reactive carbonyl chloride group.
• Academic & R&D: Employed in university and institutional laboratories for fundamental research in heterocyclic and medicinal chemistry.

Basic Information

Product Name	5-Pyrimidinecarbonyl Chloride, 1,2,3,4-Tetrahydro-2,4-Dioxo- (7Ci,8Ci,9Ci)
CAS No.	3346-68-7
Molecular Formula	C5H3ClN2O3
Molecular Weight	174.54 g/mol
Synonyms	2,4-Dioxo-1,2,3,4-tetrahydropyrimidine-5-carbonyl chloride; Uracil-5-carbonyl chloride; 5-Carboxyuracil chloride; 5-(Chlorocarbonyl)uracil; 1H-Pyrimidine-2,4-dione-5-carbonyl chloride; 5-Pyrimidinecarbonyl chloride, 1,2,3,4-tetrahydro-2,4-dioxo-; 2,4(1H,3H)-Pyrimidinedione-5-carbonyl chloride
EINECS	Contact for details

Quality Control

Our production of 5-Pyrimidinecarbonyl Chloride adheres to stringent in-process controls to ensure batch-to-batch consistency and high purity. Every lot is characterized by modern analytical techniques including HPLC, NMR, and IR spectroscopy. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Due to its hygroscopic (moisture-sensitive) nature, store under an inert atmosphere (e.g., nitrogen or argon) in a cool, dry place. Recommended storage temperature is 2-8°C for long-term stability. Keep away from moisture, strong bases, and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in polar aprotic solvents (e.g., DMF, DMSO)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.