Description

Pivaloyl Chloride is a versatile and highly reactive acyl chloride derivative of pivalic acid. Its primary value lies in its role as a key acylating agent and building block in advanced organic synthesis, offering steric bulk that can direct reaction pathways and improve product stability. This compound is essential for manufacturers in the pharmaceutical, agrochemical, and specialty polymer industries, where it is used to introduce the pivaloyl (trimethylacetyl) group into target molecules.

Application

• Pharmaceutical Intermediates: Key reagent in the synthesis of active pharmaceutical ingredients (APIs), particularly for introducing protective groups or modifying drug molecule backbones.
• Agrochemical Synthesis: Used in the production of herbicides, fungicides, and plant growth regulators as a crucial acylating agent.
• Polymer Chemistry: Acts as a monomer or modifying agent in the production of specialty polymers, including polyamides and polyesters with enhanced properties.
• Peptide Synthesis: Employed as a coupling agent or for the introduction of the pivaloyl (Piv) protecting group on amino acids.
• Dye and Pigment Manufacturing: Serves as an intermediate in the synthesis of complex organic dyes and colorants.
• Organic Synthesis Reagent: A fundamental reagent for Friedel-Crafts acylation and other acyl transfer reactions in research and development.
• Lubricant and Fuel Additives: Used in the synthesis of performance-enhancing additives.

Basic Information

Product Name	Pivaloyl Chloride
CAS No.	3282-30-2
Molecular Formula	C5H9ClO
Molecular Weight	120.58 g/mol
Synonyms	Trimethylacetyl chloride; 2,2-Dimethylpropionyl chloride; Pivalyl chloride; Neopentanoyl chloride; 2,2-Dimethylpropanoic acid chloride; tert-Butylcarbonyl chloride; Pivalic acid chloride
EINECS	221-921-9

Quality Control

Our Pivaloyl Chloride is produced under stringent quality management systems. Every batch undergoes rigorous analytical testing to ensure it meets the high-purity standards required for sensitive synthetic applications. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as assay, purity, and impurity profiles. Our quality commitment supports compliance with cGMP and other relevant regulatory frameworks for industrial and fine chemical use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area away from heat sources and incompatible materials. Due to its hygroscopic and highly volatile nature, containers must be kept tightly sealed under an inert atmosphere (e.g., nitrogen) to prevent moisture absorption and decomposition. Recommended storage temperature: 2-8°C for extended stability.

Specification

Item	Specification
Appearance	Clear, colorless to pale yellow liquid
Identification (IR)	Conforms
Assay (GC)	≥ 98.0%
Purity (GC Area %)	≥ 99.0%
Water Content (Karl Fischer)	≤ 0.1%
Acidity (as HCl)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.