Description

9-(2', 3', 5'-Tri-o-Benzyl-β-D-Arabinofuranosyl)-Adenine is a protected nucleoside derivative, a crucial intermediate in the synthesis of complex oligonucleotides and modified nucleic acids. Its primary value lies in enabling precise chemical modifications for advanced research in medicinal chemistry and molecular biology. This high-purity building block is essential for pharmaceutical R&D teams, diagnostic developers, and academic researchers working on antisense oligonucleotides, siRNA, and novel therapeutic agents targeting genetic diseases.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel antiviral and anticancer nucleoside analogs.
• Oligonucleotide Synthesis: Used in solid-phase and solution-phase synthesis to introduce modified adenine bases with protected sugar moieties.
• Prodrug Development: Serves as a precursor for creating prodrugs with enhanced bioavailability and targeted delivery.
• Biochemical Research: Critical for studying nucleic acid structure, function, and enzyme interactions.
• Diagnostic Probe Synthesis: Employed in the manufacture of labeled probes for genetic testing and molecular diagnostics.
• Antisense & siRNA Therapeutics: A foundational material for developing next-generation genetic medicines.

Basic Information

Product Name	9-(2', 3', 5'-Tri-o-Benzyl-β-D-Arabinofuranosyl)-Adenine
CAS No.	3257-73-6
Molecular Formula	C31H31N5O4
Molecular Weight	537.61 g/mol
Synonyms	9-(2',3',5'-Tri-O-benzyl-β-D-arabinofuranosyl)adenine; 2',3',5'-Tri-O-benzyladenosine; N6-Benzyladenosine derivative; 9-[(2R,3S,4R,5R)-3,4-Bis(benzyloxy)-5-[(benzyloxy)methyl]oxolan-2-yl]-9H-purin-6-amine; Protected Arabinofuranosyl Adenine; Tri-O-benzyl-ara-A; Benzylated Adenosine Arabinoside
EINECS	Contact for details

Quality Control

Every batch of 9-(2', 3', 5'-Tri-o-Benzyl-β-D-Arabinofuranosyl)-Adenine is manufactured under strict quality management systems. We provide comprehensive analytical documentation to support your regulatory filings. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available for each lot, ensuring traceability and compliance with your internal specifications and cGMP guidelines where applicable.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The compound is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Purity (HPLC, Area %)	≥ 99.0%
Single Impurity (HPLC)	≤ 0.5%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.