Description

2,2'-Anhydro-1-(5'-o-Triphenylmethyl-β-D-Arabinofuranosyl)-Uracil is a key nucleoside derivative and a vital protected intermediate in synthetic organic chemistry. This compound is essential for the controlled synthesis of modified nucleosides and oligonucleotides, enabling precise structural modifications. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of antiviral agents, antisense oligonucleotides, and other novel therapeutic nucleic acid analogs.

Application

• Pharmaceutical Intermediate: Critical building block for the synthesis of antiviral and anticancer nucleoside analogs.
• Antisense Oligonucleotide (ASO) Research: Used in the preparation of modified oligonucleotides for gene silencing and therapeutic applications.
• Prodrug Development: Serves as a protected precursor in the design of nucleoside prodrugs to enhance bioavailability and targeting.
• Medicinal Chemistry & Drug Discovery: A versatile intermediate for structure-activity relationship (SAR) studies and the creation of novel bioactive molecules.
• Biochemical Research: Employed in studies investigating nucleic acid metabolism, enzyme mechanisms, and cellular processes.
• Custom Synthesis: Supplied for bespoke chemical synthesis projects requiring high-purity, protected nucleoside frameworks.

Basic Information

Product Name	2,2'-Anhydro-1-(5'-o-Triphenylmethyl-β-D-Arabinofuranosyl)-Uracil
CAS No.	3249-94-3
Molecular Formula	C30H28N2O5
Molecular Weight	496.56 g/mol
Synonyms	5'-O-Trityl-2,2'-anhydro-1-β-D-arabinofuranosyluracil; 1-(5-O-Triphenylmethyl-β-D-arabinofuranosyl)-2,2'-anhydrouracil; 2,2'-Anhydro-1-(5-O-trityl-β-D-arabinofuranosyl)uracil; 5'-O-Trityl-2,2'-anhydrouridine; Tritylated 2,2'-Anhydrouridine; 2,2'-O-Anhydro-5'-O-trityluridine; Protected 2,2'-Anhydrouridine; 5'-O-TRT-2,2'-anhydro-Urd
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. We provide comprehensive analytical data, including HPLC purity, NMR, and mass spectrometry confirmation. Certificates of Analysis (COA) are available upon request, detailing batch-specific results for identity, purity, and impurities. Our quality management system supports development under cGMP guidelines for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere such as argon or nitrogen.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.