Description

Biphenyl-4-Yl Chlorothioformate is a specialized organosulfur reagent featuring a reactive chlorothioformate group attached to a biphenyl scaffold. This compound is valued for its role as a versatile intermediate in the synthesis of more complex molecules, particularly in pharmaceutical and agrochemical research. It is primarily sought after by R&D chemists and process development scientists working on active ingredient synthesis, material science, and the development of novel chemical entities.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of potential drug candidates, especially those containing thioester or thiocarbamate functionalities.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides.
• Polymer Chemistry: Acts as a monomer or modifying agent in the production of specialty polymers and advanced materials.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands used in catalytic systems.
• Chemical Biology Research: Employed in bioconjugation and probe development due to its reactive thioester-forming potential.
• Custom Synthesis: A critical starting material for contract research and manufacturing organizations (CROs/CMOs) producing bespoke fine chemicals.

Basic Information

Product Name	Biphenyl-4-Yl Chlorothioformate
CAS No.	3185-68-0
Molecular Formula	C13H9ClOS
Molecular Weight	248.72 g/mol
Synonyms	4-Biphenylyl Chlorothioformate; p-Phenylphenyl Chlorothioformate; (1,1'-Biphenyl)-4-yl Carbonochloridothioate; Chlorothioformic Acid O-(1,1'-Biphenyl-4-yl) Ester; 4-Biphenylyl Chlorothionoformate; 4-Phenylphenyl Chlorothioformate; Biphenyl-4-yl Chlorothionoformate
EINECS	221-704-9

Quality Control

Our Biphenyl-4-Yl Chlorothioformate is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing key parameters such as assay, identity, and impurity profiles. We adhere to cGMP principles where applicable, and our quality system is designed to meet the stringent requirements of research and development partners globally.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline solid or powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.