Description

6-Azacytidine is a potent cytidine analog and a well-characterized DNA methyltransferase (DNMT) inhibitor. This compound is a critical research tool in the fields of epigenetics and oncology, enabling the study of gene expression regulation and cellular reprogramming. It is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and life sciences sectors, particularly for applications in drug discovery, cancer research, and the development of novel therapeutic agents targeting epigenetic pathways.

Application

• Epigenetic Research: As a DNA methyltransferase inhibitor, it is used to induce DNA demethylation and study gene silencing mechanisms.
• Oncology and Cancer Research: Investigated for its potential to reactivate tumor suppressor genes and as a chemotherapeutic agent in preclinical studies.
• Stem Cell Research & Cellular Reprogramming: Employed to enhance the efficiency of induced pluripotent stem cell (iPSC) generation.
• Biochemical Assay Development: Serves as a reference standard and active component in high-throughput screening assays for epigenetic targets.
• Pharmaceutical Intermediates: Used in the synthesis and development of more advanced epigenetic drugs and prodrugs.
• Academic Research: A fundamental reagent for studying cellular differentiation, aging, and other epigenetically regulated processes.

Basic Information

Product Name	6-Azacytidine
CAS No.	3131-60-0
Molecular Formula	C8H12N4O5
Molecular Weight	244.20 g/mol
Synonyms	5-Azacytidine; Azacitidine; Ladakamycin; 4-Amino-1-β-D-ribofuranosyl-1,3,5-triazin-2(1H)-one; 1-β-D-Ribofuranosyl-4-amino-1,3,5-triazin-2(1H)-one; NSC-102816; CCRIS 401; U-18496; Vidaza (brand name)
EINECS	221-512-8

Quality Control

Our 6-Azacytidine is manufactured under strict quality systems to ensure high purity and batch-to-batch consistency, suitable for research and development applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. While we offer various grades, our standard material is characterized using advanced analytical techniques including HPLC, NMR, and mass spectrometry to meet the exacting requirements of the scientific community.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and potency. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Assay (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.5%
Heavy Metals	≤20 ppm
Related Substances (HPLC)	Individual impurity ≤0.5%; Total impurities ≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.