Description

4-Hydroxyestrone is a significant endogenous metabolite of estradiol and estrone, playing a crucial role in estrogen metabolism pathways. This compound is essential for research into hormonal balance, carcinogenesis, and the development of biomarkers for estrogen-related conditions. It is primarily utilized by pharmaceutical R&D laboratories, clinical research organizations, and academic institutions focused on endocrinology, oncology, and analytical chemistry.

Application

• Biochemical Research: Used as a high-purity reference standard in studies of estrogen metabolism and hormonal pathways.
• Pharmaceutical Development: Serves as a key intermediate or analytical standard in the research and quality control of hormone-based therapeutics.
• Clinical Diagnostics: Employed as a calibration standard in mass spectrometry and HPLC methods for quantifying estrogen metabolites in biological samples.
• Toxicology Studies: Utilized in research investigating the role of estrogen metabolites in disease etiology and cellular mechanisms.
• Academic Research: A critical reagent for universities and institutes studying endocrinology, cancer research, and metabolic disorders.

Basic Information

Product Name	4-Hydroxyestrone
CAS No.	3131-23-5
Molecular Formula	C18H22O3
Molecular Weight	286.36 g/mol
Synonyms	1,3,5(10)-Estratriene-3,4,17β-triol; 4-Hydroxy-17β-estrone; 3,4,17β-Trihydroxy-1,3,5(10)-estratriene; 4-OHE1; Estra-1,3,5(10)-triene-3,4,17β-triol; 4-Hydroxyoestrone; 4-OH-Estrone
EINECS	221-526-9

Quality Control

Our 4-Hydroxyestrone is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; ensure containers are sealed immediately after use to minimize exposure to air and humidity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.